INT1512

Context Info Confidence 0.48 First Reported 1978 Last Reported 2010 Negated 5 Speculated 0 Reported most in Abstract Documents 73 Total Number 81 Disease Relevance 26.22 Pain Relevance 20.63

extracellular region (Prl)

Anatomy Link Frequency plasma 9 liver 6 pituitary 4 brain 3 macrophage 2 Prl (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 46 100.00 Inflammation 31 100.00 opiate 20 100.00 Opioid 19 100.00 opioid receptor 4 100.00 Morphine 35 99.84 Pain 19 99.84 anesthesia 18 99.64 Enkephalin 6 99.54 carpal tunnel syndrome 11 99.42

Disease Link Frequency Relevance Heat INFLAMMATION 36 100.00 Carpal Tunnel Syndrome 17 100.00 Eclampsia 3 100.00 Schizophrenia 108 99.82 Reprotox - General 2 427 99.80 Movement Disorders 90 99.76 Depression 25 99.76 Prolactinoma 23 99.76 Hypoactive Sexual Desire Disorder 1 99.76 Cancer 8 99.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this work we have studied the binding of PRL in the male rat brain following morphine administration by both subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections.

PRL Binding (binding) of in brain associated with intracerebroventricular and morphine

1) Confidence 0.48 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.37

It was suggested that the down-regulation in PRL binding to some extent at least resulted from receptor overstimulation caused by the morphine-induced elevation in the concentrations of the endogenous hormone.

PRL Binding (binding) of associated with morphine

2) Confidence 0.48 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.42

In addition, these data provide evidence that a complex time-dependent binding of prolactin may occur in the plasma of the female rat liver.

prolactin Binding (binding) of in liver

3) Confidence 0.48 Published 1978 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 210063 Disease Relevance 0 Pain Relevance 0.06

Effect of the association time of in vivo bound prolactin on the [125I]prolactin receptor assays of female rat livers.

prolactin Binding (bound) of in livers

4) Confidence 0.48 Published 1978 Journal Mol. Cell. Endocrinol. Section Title Doc Link 210063 Disease Relevance 0 Pain Relevance 0.09

Role of prolactin-opiate interactions in the central regulation of pain threshold.

prolactin Binding (interactions) of associated with pain, pain threshold and opiate

5) Confidence 0.48 Published 1983 Journal Cephalalgia Section Title Doc Link 6311424 Disease Relevance 0.27 Pain Relevance 0.73

It is suggested that the present findings may be of significance in the understanding of the interaction of the opioids, dopamine, and prolactin in the regulation of prolactin secretion.

prolactin Binding (interaction) of associated with dopamine and opioid

6) Confidence 0.48 Published 1983 Journal Brain Res. Section Abstract Doc Link 6683117 Disease Relevance 0 Pain Relevance 0.52

The decrease in prolactin binding was contrasted by elevated plasma levels of the hormone.

prolactin Binding (binding) of in plasma

7) Confidence 0.48 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8307182 Disease Relevance 0 Pain Relevance 0.40

The effect of chronically given morphine on the binding of ovine prolactin (oPRL) to specific areas in the male rat brain was studied.

prolactin Binding (binding) of in brain associated with morphine

8) Confidence 0.48 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8307182 Disease Relevance 0 Pain Relevance 0.36

Modifications in prolactin specific binding in the rat liver induced by different non-steroidal anti-inflammatory drugs (indomethacin, piroxicam, ketoprofen, phenylbutazone, mefenamic acid and acetylsalicylic acid) have been studied.

prolactin Binding (binding) of in liver associated with aspirin, inflammation and cinod

9) Confidence 0.48 Published 1984 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6143813 Disease Relevance 0.17 Pain Relevance 0.25

The degree of inhibitory activity on prolactin binding is related to the anti-inflammatory activity of each drug, which supports the hypothesis of an involvement of prostaglandin synthesis.

prolactin Binding (binding) of associated with inflammation

10) Confidence 0.48 Published 1984 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6143813 Disease Relevance 0.26 Pain Relevance 0.25

An interaction between estrogen, progesterone and prolactin has been shown during the regression of the CL of the rat estrous cycle [34].

prolactin Binding (interaction) of

11) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.42 Pain Relevance 0.09

Elevated prolactin was not associated with sexual dysfunction among males in the overall population or among males treated with conventional antipsychotics.

prolactin Binding (associated) of associated with reprotox - general 2

12) Confidence 0.47 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695222 Disease Relevance 0.51 Pain Relevance 0

As prolactin was not associated with movement disorders, it is not likely a mediator for the relationship between movement and sexual functions.

prolactin Binding (associated) of associated with movement disorders

13) Confidence 0.47 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695222 Disease Relevance 1.68 Pain Relevance 0

The associations between prolactin and estradiol, and between estradiol and sexual dysfunction, were not significant.

prolactin Binding (associations) of associated with reprotox - general 2

14) Confidence 0.47 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695222 Disease Relevance 1.41 Pain Relevance 0.03

Conventional antipsychotics and risperidone were included in the study due to their associations with elevated prolactin.

prolactin Binding (associations) of

15) Confidence 0.47 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695222 Disease Relevance 0.64 Pain Relevance 0.09

CONCLUSION: DHEA-S was negatively associated, and prolactin positively associated with musculo-skeletal pain and psychological distress.

prolactin Binding (associated) of

16) Confidence 0.42 Published 2004 Journal Psychoneuroendocrinology Section Body Doc Link 14575729 Disease Relevance 0.11 Pain Relevance 0

Prolactin has been associated with many effects and has been implicated in the pathogenesis of pregnancy-related hypertensive disorders, although little is known about its vascular effects.

Prolactin Binding (associated) of associated with hypertension

17) Confidence 0.40 Published 2007 Journal Endocrinology Section Abstract Doc Link 17463060 Disease Relevance 0.17 Pain Relevance 0

Mating stimuli received by female rats activate a neuroendocrine mnemonic system which produces daily diurnal and nocturnal prolactin (PRL) surges for the first half of gestation, surges which help maintain corpora lutea function and a viable pregnancy.

PRL Binding (surges) of

18) Confidence 0.37 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336523 Disease Relevance 0 Pain Relevance 0.17

Mating stimuli received by female rats activate a neuroendocrine mnemonic system which produces daily diurnal and nocturnal prolactin (PRL) surges for the first half of gestation, surges which help maintain corpora lutea function and a viable pregnancy.

prolactin Binding (surges) of

19) Confidence 0.37 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336523 Disease Relevance 0 Pain Relevance 0.17

We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.

PRL Neg (not) Binding (concentrations) of in pituitary associated with fluoxetine

20) Confidence 0.37 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.26

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