INT151216

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) kinase activity (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
paw 1
Adrbk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 7 99.52 Very High Very High Very High
Thermal hyperalgesia 1 99.04 Very High Very High Very High
IPN 2 98.32 Very High Very High Very High
allodynia 1 97.60 Very High Very High Very High
agonist 11 96.36 Very High Very High Very High
Inflammation 5 96.00 Very High Very High Very High
chemokine 1 93.40 High High
opioid receptor 5 83.92 Quite High
Lasting pain 1 83.12 Quite High
Hyperalgesia 7 76.16 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 8 99.04 Very High Very High Very High
Inflammatory Pain 2 98.32 Very High Very High Very High
Neuropathic Pain 2 97.60 Very High Very High Very High
INFLAMMATION 3 96.00 Very High Very High Very High
Pain 1 83.12 Quite High
Neuroblastoma 3 75.00 Quite High
Cancer 1 33.20 Quite Low
Necrosis 1 32.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GRK2(+/-) mice with an approximately 50% reduction in GRK2 developed increased and markedly prolonged thermal hyperalgesia and mechanical allodynia after carrageenan-induced paw inflammation or after intraplantar injection of the GPCR-binding chemokine CCL3.
Positive_regulation (increased) of GRK2 in paw associated with chemokine, inflammation, allodynia and thermal hyperalgesia
1) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20147541 Disease Relevance 0.77 Pain Relevance 0.79
In conclusion, hDOP-R desensitization upon etorphine exposure relies on the GRK2, PKC and tyrosine kinases while DPDPE and deltorphin I mediate desensitization at least via tyrosine kinases.
Positive_regulation (mediate) of GRK2 associated with immobilon
2) Confidence 0.32 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18395423 Disease Relevance 0.13 Pain Relevance 0.50

General Comments

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