INT151229

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.13
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 11
Cxam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 135 99.60 Very High Very High Very High
methadone 3 98.28 Very High Very High Very High
Arthritis 87 97.48 Very High Very High Very High
Inflammatory response 20 93.96 High High
Morphine 2 92.64 High High
opiate 4 76.24 Quite High
cytokine 51 76.00 Quite High
withdrawal 4 75.28 Quite High
lidocaine 1 74.48 Quite High
chemokine 5 64.52 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 176 99.80 Very High Very High Very High
Intestinal Cancer 16 99.80 Very High Very High Very High
INFLAMMATION 164 99.60 Very High Very High Very High
Cancer 259 98.72 Very High Very High Very High
Necrosis 27 98.44 Very High Very High Very High
Targeted Disruption 53 98.40 Very High Very High Very High
Infection 130 98.04 Very High Very High Very High
Arthritis 91 97.48 Very High Very High Very High
Disease 47 94.40 High High
Helicobacter Infection 40 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We now report similar observations using human cultured monocyte-derived macrophages (hMDM) from a control population and from methadone patients.
Positive_regulation (derived) of macrophages in macrophages associated with methadone
1) Confidence 0.15 Published 2008 Journal J. Neuroimmunol. Section Abstract Doc Link 18396338 Disease Relevance 0.06 Pain Relevance 0.65
Arthritis induction but not IVIG protection was observed in colony stimulating factor-1-deficient mice (op/op), demonstrating that colony stimulating factor-1-dependent macrophages were responsible for IVIG protection in this antibody-induced arthritis model [128].
Positive_regulation (stimulating) of macrophages in macrophages associated with arthritis
2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.56 Pain Relevance 0.27
-catenin activity in gastric cancer cells by activated macrophages and TNF-?
Positive_regulation (activated) of macrophages in macrophages associated with stomach cancer
3) Confidence 0.05 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.30 Pain Relevance 0
Activated macrophages promote Wnt signalling through tumour necrosis factor-?
Positive_regulation (Activated) of macrophages in macrophages associated with necrosis and cancer
4) Confidence 0.05 Published 2008 Journal EMBO J Section Title Doc Link PMC2413189 Disease Relevance 0.61 Pain Relevance 0
Although it remains to be elucidated as to whether the loss of the CSF-1 function affects tumorigenesis, these results suggest that macrophages were required for the growth of Wnt/?
Positive_regulation (required) of macrophages in macrophages
5) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.05 Pain Relevance 0
These results indicate that the soluble factor(s) derived from activated macrophages promote the Wnt/?
Positive_regulation (activated) of macrophages in macrophages
6) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.39 Pain Relevance 0.05
Requirement of macrophages for intestinal tumour development in Apc?
Positive_regulation (Requirement) of macrophages in macrophages associated with intestinal cancer
7) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.26 Pain Relevance 0.05
Therefore, it is also possible that activated macrophages suppress ?
Spec (possible) Positive_regulation (activated) of macrophages in macrophages
8) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.52 Pain Relevance 0.03
derived from activated macrophages promotes the Wnt/?
Positive_regulation (activated) of macrophages in macrophages
9) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.38 Pain Relevance 0.10
is a key mediator for inflammation and is produced by activated macrophages.
Positive_regulation (activated) of macrophages in macrophages associated with inflammation
10) Confidence 0.03 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.40 Pain Relevance 0.05
Bone marrow macrophages were derived from the femur and tibia of C57B/6 and knockout mice and differentiated in DMEM media containing 20% L-929 supernatant.
Positive_regulation (derived) of macrophages in macrophages associated with targeted disruption
11) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.60 Pain Relevance 0.15

General Comments

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