INT151230

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.89
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
synovial fluid 1
stromal cells 1
juvenile 1
lymphoid tissue 1
apoptotic cell 1
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 687 99.84 Very High Very High Very High
Inflammation 183 99.70 Very High Very High Very High
withdrawal 3 98.16 Very High Very High Very High
Arthritis 32 97.68 Very High Very High Very High
cytokine 235 97.36 Very High Very High Very High
Inflammatory response 24 95.00 High High
Kinase C 1 86.64 High High
chemokine 36 81.92 Quite High
antagonist 4 69.64 Quite High
tolerance 10 68.28 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 690 99.84 Very High Very High Very High
Lymphopenia 75 99.82 Very High Very High Very High
INFLAMMATION 210 99.70 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 222 99.64 Very High Very High Very High
Disease 206 98.36 Very High Very High Very High
Arthritis 27 97.68 Very High Very High Very High
Apoptosis 58 97.48 Very High Very High Very High
Death 38 96.00 Very High Very High Very High
Systemic Inflammatory Response Syndrome 23 95.28 Very High Very High Very High
Shock 1 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most importantly, there was no increase in serum IL-7 levels in RA, as compared with a fourfold rise in non-RA control individuals at the time of lymphopenia.
Neg (no) Positive_regulation (increase) of IL-7 associated with lymphopenia and rheumatoid arthritis
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.38 Pain Relevance 0.49
An association between higher levels of IL-7 and thymic capacity to produce new T-cells was predictable, based on the direct stimulatory effect of IL-7 on thymic activity at many stages in T-cell progenitor development [6,11,56-60] High levels of IL-7, as detected in lymphopenic control patients, could therefore result in a burst of thymic activity.
Positive_regulation (levels) of IL-7 in T-cell
2) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.09 Pain Relevance 0.31
In another study, IL-7 was elevated in RA synovial fluid but not in OA [50] and its production was associated with stromal cells in the synovium [51].
Neg (not) Positive_regulation (elevated) of IL-7 in synovial fluid associated with rheumatoid arthritis
3) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.25 Pain Relevance 0.43
Noxious heat but not experimental inflammation significantly increased IL-7 and IL-13.
Positive_regulation (increased) of IL-7 associated with inflammation
4) Confidence 0.35 Published 2008 Journal Pain Section Abstract Doc Link 18396374 Disease Relevance 0.98 Pain Relevance 0.70
We have also demonstrated low levels of lymphopenia-induced circulating IL-7 in RA patients (Fig. 4), and low basal IL-7 production from stromal cells originating from the bone marrow (Fig. 1).
Positive_regulation (circulating) of IL-7 in stromal cells associated with lymphopenia and rheumatoid arthritis
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.57 Pain Relevance 0.49
Despite continued administration of rhIL-7 through day 14 resulting in sustained increases in circulating IL-7 levels (Fig.
Positive_regulation (increases) of IL-7
6) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.12 Pain Relevance 0.04
Together, these data suggest that the observed changes reflected rhIL-7–induced increases in RTE cycling, as well as trafficking of RTEs from peripheral lymphoid tissue into the bloodstream as seen in the mouse model (25, 44), whereas no direct effect on thymopoiesis can be demonstrated in the short time span of this study.
Positive_regulation (increases) of rhIL-7 in lymphoid tissue
7) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
Increased levels of circulating IL-7 in patients with RA and juvenile idiopathic (rheumatoid) arthritis [30,33] correlated with increased parameters of disease.
Positive_regulation (Increased) of IL-7 in juvenile associated with rheumatoid arthritis, disease and arthritis
8) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.14 Pain Relevance 0.36
Recent studies have shown that IL-7 is produced by activated synovial fibroblasts from RA patients [29], and that circulating levels of IL-7 were shown to correlate with markers of disease [30].
Positive_regulation (levels) of IL-7 in fibroblasts associated with rheumatoid arthritis and disease
9) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.64 Pain Relevance 0.27
are dominant over Th2 cells (generating IL-10 and leading to IL-7 activation).
Positive_regulation (activation) of IL-7 in Th2 cells
10) Confidence 0.13 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.83 Pain Relevance 0.15
A more recent report emphasized the particular role of IL-7 for RA [40].
Positive_regulation (role) of IL-7 associated with rheumatoid arthritis
11) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.55 Pain Relevance 0.39
and IL-7 were elevated in all patients.
Positive_regulation (elevated) of IL-7
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.39
Lymphocytes require IL-2, IL-4, IL-7, IL-9 and IL-15 for viability [252,253], and withdrawal of these cytokines leads to apoptotic cell death.
Positive_regulation (require) of IL-7 in apoptotic cell associated with apoptosis, withdrawal, death and cytokine
13) Confidence 0.02 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 0.95 Pain Relevance 0.29
Increasing levels of CRP, D-dimer, IL-1RA, IL-6, IL-7, IL-13, or G-CSF following initiation of ART were associated with increasing hazard of IRIS (each p?
Positive_regulation (Increasing) of IL-7 associated with immune reconstitution inflammatory syndrome
14) Confidence 0.01 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.15 Pain Relevance 0.24

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