INT151260

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.83
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Nfib) nucleus (Nfib) intracellular (Nfib)
DNA binding (Nfib)
Anatomy Link Frequency
brain 2
thymocytes 1
Nfib (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 5 99.56 Very High Very High Very High
Sciatic nerve 2 99.28 Very High Very High Very High
Hippocampus 31 96.20 Very High Very High Very High
Thalamus 1 95.68 Very High Very High Very High
Spinal cord 8 94.72 High High
cytokine 9 93.24 High High
Pain 4 90.72 High High
Inflammation 3 87.44 High High
Peripheral nerve injury 1 80.80 Quite High
nMDA receptor antagonist 1 72.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Injury 6 99.56 Very High Very High Very High
Reprotox - General 1 3 99.36 Very High Very High Very High
Urological Neuroanatomy 1 97.00 Very High Very High Very High
Targeted Disruption 83 92.52 High High
Pain 4 90.72 High High
Weight Gain 18 89.68 High High
INFLAMMATION 3 87.44 High High
Nervous System Injury 1 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene expression of tumor necrosis factor-alpha (TNF), interleukin (IL)-1beta, IL-4, and IL-10 was analyzed by quantitative real-time-PCR from 1 to 12 h after surgery or until values were back to baseline.
Gene_expression (expression) of 1beta associated with necrosis and cancer
1) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18400394 Disease Relevance 1.07 Pain Relevance 1.06
We had shown previously that Nfia, Nfib and Nfix are all expressed in both prenatal and adult brains [8], and that loss of either Nfia or Nfib results in defects in brain development [12,13,16].
Gene_expression (expressed) of Nfib in brain
2) Confidence 0.63 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.30 Pain Relevance 0
10% of thymocytes showed GFP expression (Fig. 1 B), and the large majority (89%) of GFP+ thymocytes was CD4+CD8+ (double positive; Fig. 1 B).
Gene_expression (expression) of 1 B in thymocytes
3) Confidence 0.58 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882844 Disease Relevance 0.14 Pain Relevance 0
Extracts of JEG3 choriocarcinoma cells transfected with vectors expressing N-terminal HA-tagged versions of NFIA, NFIB, NFIC and NFIX were subjected to SDS-polyacrylamide gel electrophoresis and Western blot analysis as described previously [8].
Gene_expression (expressing) of NFIB associated with reprotox - general 1
4) Confidence 0.56 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.10 Pain Relevance 0
Previous studies showed that both Nfia and Nfib are essential for normal brain development [12,13,16].
Gene_expression (essential) of Nfib in brain
5) Confidence 0.55 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.21 Pain Relevance 0

General Comments

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