INT151261

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.12
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Nfib) nucleus (Nfib) intracellular (Nfib)
DNA binding (Nfib)
Anatomy Link Frequency
brain 2
spinal cord 1
corpus callosum 1
lung 1
Nfib (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 5 99.66 Very High Very High Very High
Spinal cord 12 98.08 Very High Very High Very High
Sciatic nerve 2 90.48 High High
Hippocampus 51 87.40 High High
nMDA receptor antagonist 1 87.04 High High
Thalamus 1 86.88 High High
cytokine 9 84.44 Quite High
Pain 2 81.92 Quite High
Inflammation 1 78.64 Quite High
Peripheral nerve injury 1 72.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 135 100.00 Very High Very High Very High
Injury 5 99.66 Very High Very High Very High
Hydrocephalus 40 92.40 High High
Necrosis 1 92.32 High High
Cancer 6 91.96 High High
Urological Neuroanatomy 1 88.20 High High
Weight Gain 30 86.48 High High
Pain 2 81.92 Quite High
INFLAMMATION 1 78.64 Quite High
Nervous System Injury 1 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes seen in Nfix-/- brains are quite distinct from those seen with loss of either Nfia or Nfib.
Negative_regulation (loss) of Nfib in brains
1) Confidence 0.47 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.28 Pain Relevance 0
We had shown previously that Nfia, Nfib and Nfix are all expressed in both prenatal and adult brains [8], and that loss of either Nfia or Nfib results in defects in brain development [12,13,16].
Negative_regulation (loss) of Nfib in brain
2) Confidence 0.47 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.34 Pain Relevance 0
CCI led to an early downregulation of TNF and IL-1beta mRNA in distinct brain areas and in the lumbar spinal cord with a maximum decrease within the first 6h after CCI.
Negative_regulation (downregulation) of 1beta in spinal cord associated with eae and spinal cord
3) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18400394 Disease Relevance 1.01 Pain Relevance 1.02
Similarly, loss of Nfib is also associated with midline glial cell defects and agenesis of the corpus callosum [16].
Negative_regulation (loss) of Nfib in corpus callosum
4) Confidence 0.35 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.09 Pain Relevance 0.04
Targeted disruption of Nfib also results in callosal agenesis and other neuroanatomical defects, but Nfib-/- animals die at birth, apparently due to a severe delay in lung maturation [16].
Negative_regulation (disruption) of Nfib in lung associated with targeted disruption
5) Confidence 0.35 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.29 Pain Relevance 0.05
We showed previously that in both Nfia and Nfib knockout mice those populations were disrupted [13,16], implicating NFIA and NFIB in their development.
Negative_regulation (disrupted) of Nfib associated with targeted disruption
6) Confidence 0.15 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.10 Pain Relevance 0

General Comments

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