INT151268

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.65
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 1
DRG 1
microglia 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.68 Very High Very High Very High
Eae 5 99.32 Very High Very High Very High
Morphine 14 99.28 Very High Very High Very High
Endep 11 99.10 Very High Very High Very High
intrathecal 5 96.80 Very High Very High Very High
Antinociceptive 2 88.80 High High
Sciatic nerve 59 85.12 High High
Neuropathic pain 11 80.24 Quite High
Glutamate 5 75.00 Quite High
excitatory amino acid 3 69.12 Quite High
Disease Link Frequency Relevance Heat
Injury 29 99.32 Very High Very High Very High
Neuropathic Pain 97 80.24 Quite High
Necrosis 3 75.00 Quite High
Cancer 3 75.00 Quite High
Infarction 8 69.28 Quite High
Nervous System Injury 5 66.72 Quite High
INFLAMMATION 46 62.44 Quite High
Brain Hemorrhage 8 54.36 Quite High
Diabetes Mellitus 204 52.96 Quite High
Stroke 17 40.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Phosphorylation (phosphorylation) of p65 in nucleus associated with endep and morphine
1) Confidence 0.61 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.85
Treating rat primary microglia with BW-B70C confirmed blockage of LPS-mediated translocation of the p65 subunit of NF-?
Phosphorylation (subunit) of p65 in microglia
2) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.06
Interestingly, CCI remarkably elevated IKKalpha and p65 phosphorylations in the spinal cord rather than in the DRG.
Phosphorylation (phosphorylations) of p65 in DRG associated with eae and spinal cord
3) Confidence 0.24 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.17 Pain Relevance 0.86
B p65 (Santa Cruz Biotechnology, Santa Cruz, CA), or mouse anti–phospho-p65 NF-?
Phosphorylation (phospho) of p65
4) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 0.10 Pain Relevance 0.09
B p65 (Santa Cruz Biotechnology, Santa Cruz, CA), or mouse anti–phospho-p65 NF-?
Phosphorylation (phospho) of p65
5) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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