INT15127

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.06
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd2) protein complex (Cd2)
Cd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
tetrodotoxin 3 99.90 Very High Very High Very High
Morphine 3 99.44 Very High Very High Very High
noradrenaline 3 98.02 Very High Very High Very High
monoamine 1 97.36 Very High Very High Very High
agonist 4 96.72 Very High Very High Very High
ASIC 18 95.72 Very High Very High Very High
Clonidine 2 94.56 High High
Enkephalin 1 89.92 High High
Disease Link Frequency Relevance Heat
Acidosis 141 98.96 Very High Very High Very High
Adhesions 1 92.88 High High
Rheumatoid Arthritis 4 78.16 Quite High
Low Back Pain 2 75.00 Quite High
Systemic Lupus Erythematosus 2 75.00 Quite High
Lyme Disease 2 75.00 Quite High
Pain 6 64.20 Quite High
Hypoxia 62 50.00 Quite Low
Cv Unclassified Under Development 18 5.00 Very Low Very Low Very Low
Acid Base Imbalance 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of presynaptic alpha 2-adrenoceptors with phentolamine, almost doubling K+-induced 3H-noradrenaline release, slightly enhanced the relative inhibitory effects of morphine and DADLE, whereas that of Cd2+ remained unaffected.
Neg (unaffected) Regulation (unaffected) of Cd2 associated with noradrenaline and morphine
1) Confidence 0.44 Published 1986 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3022159 Disease Relevance 0 Pain Relevance 0.84
In TTX and Cd2+, which prevented dopamine release, the D1 antagonist had no effect on miniature IPSCs.
Neg (no) Regulation (effect) of Cd2 associated with tetrodotoxin, dopamine and antagonist
2) Confidence 0.32 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482788 Disease Relevance 0 Pain Relevance 1.06
CD2R is an activation-associated epitope unmasked by a conformational change of the CD2 cell-surface glycoprotein.
Regulation (change) of CD2
3) Confidence 0.27 Published 1991 Journal Scand. J. Immunol. Section Abstract Doc Link 1715605 Disease Relevance 0.83 Pain Relevance 0.29
We also tested the effects of Ni2+ and Cd2+ on the Ca2+ response to acidosis.
Regulation (effects) of Cd2 associated with acidosis
4) Confidence 0.19 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.23 Pain Relevance 0.18

General Comments

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