INT151274

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Anatomy Link Frequency
T cells 4
plaque 2
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 15 98.52 Very High Very High Very High
cytokine 11 92.40 High High
Inflammation 16 73.00 Quite High
Central nervous system 7 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 70 99.54 Very High Very High Very High
Diabetes Mellitus 14 98.84 Very High Very High Very High
Opportunistic Infections 9 98.04 Very High Very High Very High
Autoimmune Disease 17 97.36 Very High Very High Very High
Infection 34 83.52 Quite High
Cancer 2 76.40 Quite High
Necrosis 3 75.92 Quite High
Lymphopenia 18 73.04 Quite High
INFLAMMATION 14 73.00 Quite High
Parasitemia 14 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD40L blockade does not prevent the induction of autoimmune diabetes by memory-like T cells
Negative_regulation (prevent) of Gene_expression (blockade) of CD40L in T cells associated with diabetes mellitus
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.47 Pain Relevance 0.20
CONCLUSION: We concluded that, statin treatment may decrease the expression of CD40L on plaque T lymphocytes in patients with stable angina pectoris.


Negative_regulation (decrease) of Gene_expression (expression) of CD40L in plaque
2) Confidence 0.28 Published 2008 Journal Anadolu Kardiyol Derg Section Body Doc Link 18400628 Disease Relevance 0 Pain Relevance 0
In CD4+ T cells from HIV infected patients the expression of CD154 was impaired in response to a number of pathogens including T. gondii.
Negative_regulation (impaired) of Gene_expression (expression) of CD154 in T cells associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.08 Published 2004 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC420481 Disease Relevance 1.69 Pain Relevance 0.10

General Comments

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