INT151309

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.62
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
articular cartilage 4
synovial fluid 2
chondrocytes 2
cervix 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 159 100.00 Very High Very High Very High
Osteoarthritis 262 93.96 High High
chemokine 2 73.08 Quite High
cytokine 56 71.20 Quite High
Pain 49 66.52 Quite High
Inflammation 75 59.24 Quite High
antagonist 6 45.48 Quite Low
Inflammatory response 8 33.48 Quite Low
Arthritis 26 5.00 Very Low Very Low Very Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 122 98.80 Very High Very High Very High
Knee Osteoarthritis 134 93.96 High High
Cumulative Trauma Disorders 1 78.88 Quite High
Rupture 9 77.52 Quite High
Tendon Injuries 1 69.84 Quite High
Pain 35 66.52 Quite High
INFLAMMATION 93 59.24 Quite High
Premature Birth 6 51.84 Quite High
Frailty 116 50.00 Quite Low
Osteoarthritis 18 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin E2, for instance, induces activation of MMP-3, but does not affect MMP-3 total protein in the rat cervix (Chien et al., 2005).
Positive_regulation (induces) of Positive_regulation (activation) of MMP-3 in cervix associated with metalloproteinase
1) Confidence 0.60 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.05 Pain Relevance 0.19
However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded culture.
Positive_regulation (changing) of Positive_regulation (changes) of MMP3
2) Confidence 0.42 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18404723 Disease Relevance 0.36 Pain Relevance 0.10
Studies with cartilage explants that are subjected to mechanical impact injury demonstrate that the remaining viable chondrocytes express increased levels of matrix metalloproteinase (MMP)-1, MMP-3, MMP-8, MMP-9, MMP-13 and ADAM-TS5 [46,47].
Positive_regulation (increased) of Positive_regulation (levels) of MMP-3 in chondrocytes associated with injury and metalloproteinase
3) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.36 Pain Relevance 0.38
Analyses of synovial fluid samples taken from patients after an ACL or meniscal tear revealed increased MMP-3 levels that remained elevated for many years [48].
Positive_regulation (elevated) of Positive_regulation (increased) of MMP-3 in synovial fluid associated with metalloproteinase
4) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.34 Pain Relevance 0.38
Elevated levels of stromelysin (MMP-3), collagenases (MMP-1, -8, and -13), and gelatinases (MMP-2 and -9) have also been found in chondrocytes or the articular cartilage surface in OA [29,31].
Positive_regulation (levels) of Positive_regulation (Elevated) of stromelysin in articular cartilage associated with osteoarthritis
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.76 Pain Relevance 0.72
Elevated levels of stromelysin (MMP-3), collagenases (MMP-1, -8, and -13), and gelatinases (MMP-2 and -9) have also been found in chondrocytes or the articular cartilage surface in OA [29,31].
Positive_regulation (Elevated) of Positive_regulation (levels) of stromelysin in articular cartilage associated with osteoarthritis
6) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.76 Pain Relevance 0.72

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