INT15131

Context Info Confidence 0.75 First Reported 1980 Last Reported 2009 Negated 1 Speculated 2 Reported most in Abstract Documents 20 Total Number 25 Disease Relevance 9.47 Pain Relevance 5.01

extracellular region (CD2) plasma membrane (CD2)

Anatomy Link Frequency natural killer cells 3 T cells 3 blood 1 juvenile 1 PBL 1 CD2 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 40 99.68 rheumatoid arthritis 20 99.04 depression 6 98.92 narcan 3 98.28 headache 6 96.48 spinal inflammation 6 95.72 Acupuncture 56 95.16 Inflammation 74 91.60 cytokine 167 91.56 Sicca syndrome 3 89.84

Disease Link Frequency Relevance Heat Acute Promyelocytic Leukemia 6 99.84 Lymphatic System Cancer 18 99.76 Rheumatoid Arthritis 20 99.04 Depression 6 98.92 Stress 37 97.16 Systemic Lupus Erythematosus 112 96.92 Headache 6 96.48 Diabetes Mellitus 5 96.24 Low Back Pain 6 95.72 Adult T-cell Leukemia-lymphoma 11 95.56

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A 1- to 3-hr incubation of addicted-derived lymphocytes with 10(-6) to 10(-7) M Naloxone reverses both T cell depression and null cell increase by allowing the null cells to express SRBC receptors.

Gene_expression (express) of SRBC in null cells associated with depression and narcan

1) Confidence 0.75 Published 1980 Journal J. Immunol. Section Abstract Doc Link 6253568 Disease Relevance 0.23 Pain Relevance 0.51

[CD2 and CD8 expression in acute promyelocytic leukemia].

Gene_expression (expression) of CD2 associated with acute promyelocytic leukemia

2) Confidence 0.68 Published 1996 Journal Rinsho Ketsueki Section Title Doc Link 8997125 Disease Relevance 0.73 Pain Relevance 0.12

Beyond day 10, however, CD3 counts were lower in the ATG-F group, as were CD2 counts, CD4 counts, and the CD4/CD8 ratio, suggesting a more prolonged immunosuppressive effect of ATG-F.

Gene_expression (counts) of CD2

3) Confidence 0.65 Published 1995 Journal Transplantation Section Abstract Doc Link 7701577 Disease Relevance 0.52 Pain Relevance 0.07

The results suggest that Tyr-MIF-1 does not directly modulate CD 2, CD 4 and CD 8 expression, does not alter the proliferative response of PBL, and does not affect the production of IL 2.

Gene_expression (expression) of CD 2 in PBL

4) Confidence 0.63 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2575445 Disease Relevance 0 Pain Relevance 0.34

Also, as expected, T11 modulation reduced the percentages of cells expressing T11.

Gene_expression (expressing) of T11

5) Confidence 0.63 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.38

Whereas all human Leu2a(+) cells expressed similar numbers of T11 receptors, monkey cells with high-density Leu2a expressed fewer T11 markers than those with low-density Leu2a.

Gene_expression (expressed) of T11

6) Confidence 0.63 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.39

Expression of the CD2 activation epitope T11-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease: phenotypic and functional analysis.

Gene_expression (Expression) of T11 in juvenile associated with spinal inflammation, lyme disease, rheumatoid arthritis and systemic lupus erythematosus

7) Confidence 0.58 Published 1991 Journal Scand. J. Immunol. Section Title Doc Link 1715605 Disease Relevance 0.94 Pain Relevance 0.34

Lymphocytes in patients with stable and unstable angina showed a similar percent expression of CD2/CD19 and CD3/HLA-DR antigens, with no difference between aortic and coronary sinus blood.

Gene_expression (expression) of CD2 in blood

8) Confidence 0.58 Published 1995 Journal J. Am. Coll. Cardiol. Section Body Doc Link 7594025 Disease Relevance 0 Pain Relevance 0

The T cells expressed CD2, CD3, CD5, CD7, and CD8, with partial loss of CD4.

Gene_expression (expressed) of CD2 in T cells

9) Confidence 0.52 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.73 Pain Relevance 0.10

Furthermore, in the single-color analyses, the effects of morphine on kinetics of T11 expression were quite similar for both human and monkey cells.

Gene_expression (expression) of T11 associated with morphine

10) Confidence 0.49 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.45

Whereas all human Leu2a(+) cells expressed similar numbers of T11 receptors, monkey cells with high-density Leu2a expressed fewer T11 markers than those with low-density Leu2a.

Gene_expression (expressed) of T11

11) Confidence 0.49 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.34

The effects of morphine on kinetics of Leu2a and T11 expression were at obvious variance between species.

Gene_expression (expression) of T11 associated with morphine

12) Confidence 0.49 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.33

In the two-color analyses, the simultaneous expression of T11 and Leu3a markers was uniform for both monkey and human cells.

Gene_expression (expression) of T11

13) Confidence 0.49 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3343706 Disease Relevance 0 Pain Relevance 0.45

The lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.

Neg (negative) Gene_expression (positive) of CD2 in T-cell associated with lymphatic system cancer

14) Confidence 0.49 Published 2003 Journal J. Gastroenterol. Section Abstract Doc Link 12743779 Disease Relevance 0.79 Pain Relevance 0.10

First, the increase of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ cell counts as well as the levels of IL-1?

Gene_expression (cell) of CD2

15) Confidence 0.45 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.40

The proportions of several cell populations (CD2, CD4, CD8,

Gene_expression (proportions) of CD2

16) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2324165 Disease Relevance 0.78 Pain Relevance 0.17

CD2 is expressed on the surface of T cells and natural killer cells.

Gene_expression (expressed) of CD2 in T cells

17) Confidence 0.34 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.37 Pain Relevance 0.08

Eight patients experienced a 50% decrease in baseline PASI and 51% of all patients experienced a decrease in PGA by at least one grade at some point in the 8-week treatment period and the dosing regimen provided a dose-dependent response.[36] Anti-CD2 antibodies

Gene_expression (antibodies) of CD2

18) Confidence 0.30 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.37 Pain Relevance 0.08

Because CD2 expression is up regulated in both CD4+ and CD8+ memory T cells (CD45RO+), agents that block CD2 will selectively inhibit the activation and proliferation of the pathogenic memory T cells.

Gene_expression (expression) of CD2 in memory T cells

19) Confidence 0.27 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.33 Pain Relevance 0.07

The strong presence of CD2, CD3, and CD4 coupled with the much weaker immunoreactivity of CD7 and CD8 was consistent with a diagnosis of ATLL.

Gene_expression (presence) of CD2 associated with adult t-cell leukemia-lymphoma

20) Confidence 0.23 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824742 Disease Relevance 0.44 Pain Relevance 0

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