INT15132

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 33
Total Number 35
Disease Relevance 20.09
Pain Relevance 5.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
Anatomy Link Frequency
plasma 2
lungs 2
T-cell 2
retina 1
CSF 1
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
Arthritis 53 99.90 Very High Very High Very High
Inflammation 421 98.96 Very High Very High Very High
Multiple sclerosis 27 98.92 Very High Very High Very High
rheumatoid arthritis 96 98.84 Very High Very High Very High
cytokine 370 98.68 Very High Very High Very High
antidepressant 40 95.52 Very High Very High Very High
spinal inflammation 9 94.20 High High
Inflammatory response 17 91.84 High High
Inflammatory mediators 15 89.52 High High
Disease Link Frequency Relevance Heat
Cancer 91 100.00 Very High Very High Very High
Necrosis 65 100.00 Very High Very High Very High
Arthritis 19 99.90 Very High Very High Very High
Spondylarthropathies 4 99.78 Very High Very High Very High
Synovitis 4 99.76 Very High Very High Very High
Rheumatic Diseases 3 99.28 Very High Very High Very High
INFLAMMATION 445 98.96 Very High Very High Very High
Disease 175 98.92 Very High Very High Very High
Demyelinating Disease 51 98.92 Very High Very High Very High
Rheumatoid Arthritis 97 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, expression of CD2R was restricted to T cells, not limited to a particular T-cell subset and not correlated with the expression of p55 interleukin 2R (IL-2R) (CD25) or major histocompatibility complex (MHC) class II molecules.
Gene_expression (expression) of p55 in T-cell
1) Confidence 0.75 Published 1991 Journal Scand. J. Immunol. Section Abstract Doc Link 1715605 Disease Relevance 0.92 Pain Relevance 0.33
Intervertebral disks from 28 donors (age 12-70 years) suffering from scoliosis, vertebrae fracture or disk degeneration were scored histologically for degeneration and analyzed for gene expression of FasL/Fas, TRAIL/DR4, TNF-alpha/TNFR1 and caspase 8.
Spec (analyzed) Gene_expression (expression) of TNFR1 in vertebrae associated with scoliosis
2) Confidence 0.75 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.82 Pain Relevance 0.12
The expression of the p75 and p55-TNF-receptors in rheumatic diseases was investigated.
Spec (investigated) Gene_expression (expression) of p55 associated with rheumatic diseases
3) Confidence 0.75 Published 1993 Journal Z Rheumatol Section Abstract Doc Link 8147132 Disease Relevance 0.96 Pain Relevance 0.22
In 4/9 patients with rheumatoid arthritis and in 6/11 patients with spondylarthropathies SMNC also expressed the p55 TNF receptor.
Gene_expression (expressed) of p55 in SMNC associated with rheumatoid arthritis and spondylarthropathies
4) Confidence 0.75 Published 1993 Journal Z Rheumatol Section Abstract Doc Link 8147132 Disease Relevance 0.96 Pain Relevance 0.29
B did not take place in the lungs of double (p55p75) TNF?
Gene_expression (lungs) of p55 in lungs
5) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.10
, soluble TNF receptor-1 and 2 (sTNFR-1 and sTNFR-2), IL-6, and IL-1?
Gene_expression (soluble) of TNF receptor-1
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713422 Disease Relevance 0 Pain Relevance 0.10
, soluble TNF receptor-1 and 2 (sTNFR-1 and sTNFR-2), IL-6, and IL-1?
Gene_expression (sTNFR-1) of TNF receptor-1
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713422 Disease Relevance 0 Pain Relevance 0.10
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (synonyms) of CD120a
8) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.44 Pain Relevance 0.36
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (expressed) of CD120a
9) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.44 Pain Relevance 0.36
B did not take place in the lungs of double (p55p75) TNF?
Gene_expression (double) of p55 in lungs
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.10
TNF interacts with two different receptors, designated TNFR1 and TNFR2, which are differentially expressed on cells and tissues and initiate both distinct and overlapping signal transduction pathways.
Gene_expression (expressed) of TNFR1
11) Confidence 0.61 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18161752 Disease Relevance 0.98 Pain Relevance 0.20
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Gene_expression (expression) of TNFR
12) Confidence 0.58 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34
Levels of tumor necrosis factor-alpha messenger RNA were significantly higher and levels of interleukin (IL)-4 messenger RNA were significantly lower in demented compared to nondemented HIV-infected patients.
Gene_expression (Levels) of tumor necrosis factor-alpha messenger RNA associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection
13) Confidence 0.48 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.62 Pain Relevance 0.20
, and TNFRSF1A expressions (r = 0.493, P < .001; r = 0.421, P = .005; r = 0.509, P < .001, resp.).
Gene_expression (expressions) of TNFRSF1A
14) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.53 Pain Relevance 0.04
In addition, intrathecal sTNF-R was also detected in the patients with non-inflammatory diseases, indicating that sTNF-R is definitively a normal constituent of CSF.
Gene_expression (detected) of sTNF-R in CSF associated with inflammation, disease and intrathecal
15) Confidence 0.39 Published 1995 Journal J. Neurol. Section Abstract Doc Link 7798123 Disease Relevance 1.35 Pain Relevance 0.35
One-way ANOVA was used to determine whether there were significant differences between EP parameters within a RI parameter, and between RI parameters within an EP parameter for the uric acid extraction.
Gene_expression (parameters) of RI
16) Confidence 0.36 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC3010161 Disease Relevance 0 Pain Relevance 0.03
B [29], the overall outcome of PAR2/TNFR1 is a loss in JNK activation only.
Gene_expression (outcome) of TNFR1
17) Confidence 0.32 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.06 Pain Relevance 0
Different modes of EP and RI (Table 1 and Figure 3) were applied via the Ag/AgCl electrodes.
Gene_expression (modes) of RI
18) Confidence 0.31 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC3010161 Disease Relevance 0 Pain Relevance 0.03
One-way ANOVA was used to determine whether there were significant differences between EP parameters within a RI parameter, and between RI parameters within an EP parameter for the uric acid extraction.
Gene_expression (parameters) of RI
19) Confidence 0.31 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC3010161 Disease Relevance 0 Pain Relevance 0.03
in the activation of pro-inflammatory signalling responses such as JNK and p38 MAP kinase in a cell line (clone G) expressing both PAR2 and TNFR1 receptors.
Gene_expression (expressing) of TNFR1 associated with inflammation
20) Confidence 0.29 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.48 Pain Relevance 0.21

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