INT151323

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.36
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2)
cytoplasm (MAP2)
Anatomy Link Frequency
neuronal 4
MAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.98 Very High Very High Very High
Dopamine 85 92.52 High High
midbrain 20 92.40 High High
tetrodotoxin 15 90.72 High High
addiction 4 71.92 Quite High
Calcium channel 3 64.96 Quite High
Glutamate 9 62.80 Quite High
antagonist 10 62.72 Quite High
Glutamate receptor 7 61.12 Quite High
potassium channel 4 53.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 7 93.04 High High
Neurodegenerative Disease 20 89.60 High High
Obesity 22 85.92 High High
Cancer 2 83.36 Quite High
Familial Dysautonomia 121 82.32 Quite High
Glioblastoma 2 81.88 Quite High
Glioma 1 75.00 Quite High
Adhesions 3 72.04 Quite High
Disease 17 52.96 Quite High
Neurological Disease 3 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical studies revealed that these networks were positive for the neuronal marker proteins beta-tubulin(III) and microtubule-associated protein 2 (MAP-2).
Positive_regulation (proteins) of MAP-2 in neuronal
1) Confidence 0.50 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19393237 Disease Relevance 0.09 Pain Relevance 0.16
Immunocytochemical studies revealed that these networks were positive for the neuronal marker proteins beta-tubulin(III) and microtubule-associated protein 2 (MAP-2).
Positive_regulation (proteins) of microtubule-associated protein 2 in neuronal
2) Confidence 0.50 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19393237 Disease Relevance 0.09 Pain Relevance 0.16
Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab).
Positive_regulation (increased) of microtubule-associated protein 2ab in neuronal associated with qutenza
3) Confidence 0.43 Published 2008 Journal Life Sci. Section Abstract Doc Link 18405923 Disease Relevance 0.49 Pain Relevance 0.86
RT-PCR analysis demonstrated that the mRNA levels encoding for ABCG2, nestin, Tuj1, MAP2, NFL, NFM, NSE, GAP43, SNAP25, GFAP, and CNPase were also highly increased in NI-hADSCs.
Positive_regulation (increased) of MAP2
4) Confidence 0.34 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.28 Pain Relevance 0.24
In agreement with previously obtained immunostaining data, TH and MAP2 levels were increased by SPIE treatment.
Positive_regulation (increased) of MAP2
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.26
After 10 days under neurogenic induction, the expression of nestin remains relatively stable, but we observed a dramatically increase of more mature neuronal proteins MAP-2 and TH, with more than 50,1% and 63,1% of positive cells respectively (Figure 2A,B).


Positive_regulation (increase) of MAP-2 in neuronal
6) Confidence 0.16 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.16 Pain Relevance 0.03
When assessing immunostaining on treated cells, we observed that rafnshh treatment increased the proportion of both GFAP (Figure 9I and J) and MAP2-expressing cells (Figure 9K and L).
Positive_regulation (increased) of MAP2-expressing
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.24 Pain Relevance 0

General Comments

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