INT15133

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Context Info
Confidence 0.34
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 5.84
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocytes 9
CD86 3
B cells 1
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 188 100.00 Very High Very High Very High
local anesthetic 12 100.00 Very High Very High Very High
Multiple sclerosis 130 99.26 Very High Very High Very High
Inflammation 167 98.64 Very High Very High Very High
Inflammatory response 69 97.16 Very High Very High Very High
cytokine 61 85.16 High High
agonist 11 80.80 Quite High
rheumatoid arthritis 6 80.24 Quite High
spinal inflammation 2 75.00 Quite High
chemokine 11 73.56 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 138 99.26 Very High Very High Very High
INFLAMMATION 207 98.64 Very High Very High Very High
Cancer 114 96.96 Very High Very High Very High
Stress 60 96.76 Very High Very High Very High
Adhesions 5 94.96 High High
Critical Illness 11 94.92 High High
Pressure Volume 2 Under Development 22 91.88 High High
Systemic Inflammatory Response Syndrome 77 91.68 High High
Nosocomial And Community Acquired Bacterial Infections 22 89.56 High High
Sepsis 77 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared to IL-10, hydrocortisone had a greater capacity to reduce the up-regulation of HLA-DR induced by PAMPs, especially on CD14HIGH monocytes.
Regulation (regulation) of HLA-DR in monocytes
1) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.16
Among the mediators produced during inflammation, cortisol [21] and IL-10 [22] were shown to contribute to the down-regulation of HLA-DR on CD14+ cells.
Regulation (regulation) of HLA-DR associated with inflammation
2) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 1.13 Pain Relevance 0.09
HLA-DR MFI absolute values for AAS and CAS before anesthesia and healthy controls on CD14LOW monocytes were 426 ± 34, 418 ± 31 and 452 ± 31, respectively.
Regulation (controls) of HLA-DR in monocytes associated with anesthesia
3) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.52
HLA-DR MFI absolute values for AAS and CAS before anesthesia and healthy controls on CD14HIGH monocytes were 282 ± 31, 285 ± 23 and 211 ± 37, respectively.
Regulation (controls) of HLA-DR in monocytes associated with anesthesia
4) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.34 Pain Relevance 0.47
Indeed, CAS, a less severe surgery, was associated with a lower down-regulation of HLA-DR and less frequent post-operative complications.
Regulation (regulation) of HLA-DR
5) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.37 Pain Relevance 0.16
Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

Introduction

Regulation (regulation) of HLA-DR in monocyte associated with inflammation
6) Confidence 0.15 Published 2010 Journal Crit Care Section Title Doc Link PMC2887183 Disease Relevance 0.36 Pain Relevance 0.09
In order to identify the mechanism of HLA-DR down-regulation on CD14HIGH and CD-14LOW monocytes, we tested various mediators produced during stress that are known to interfere with the immune response.
Regulation (regulation) of HLA-DR in monocytes associated with stress
7) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.10 Pain Relevance 0.30
The differential modulation of HLA-DR on monocyte subpopulations led us to consider that exogenous signals leading to this down-regulation could be different for each subset.
Regulation (modulation) of HLA-DR in monocyte
8) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.11 Pain Relevance 0.03
Negative correlations were found between the reduction of HLA-DR expression and the change in cortisol levels for both subpopulations, whereas a negative correlation between interleukin-10 (IL-10) levels and HLA-DR modulation was only observed for CD14HIGH cells.
Regulation (modulation) of HLA-DR
9) Confidence 0.15 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.06
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Regulation (regulation) of HLA-DR in monocytes
10) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Because HLA-DR appeared to be differently regulated on monocyte subpopulations, we also performed in vitro experiments to further identify mediators and intracellular molecules possibly involved in this process.


Regulation (regulated) of HLA-DR in monocyte
11) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.30 Pain Relevance 0.03
The effects of local anesthetics on monocyte mCD14 and HLA-DR expression were measured by dual monoclonal antibody staining and flow cytometry.
Regulation (effects) of HLA-DR in monocyte associated with local anesthetic
12) Confidence 0.15 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.30 Pain Relevance 0.89
The modulation of the cell surface molecules CD86, CD83 and HLA-DR was measured after DC exposure to known photoallergenic and phototoxic as well as allergenic and non-allergenic chemicals or to irradiation only.
Regulation (modulation) of HLA-DR in CD86
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0.04
TCF2, CXCL10, and FUT4 were all up regulated in the MS samples whereas CDC5L, TNFRSF19 and HLA-DR were down regulated (Table 5).
Regulation (regulated) of HLA-DR associated with multiple sclerosis
14) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.48 Pain Relevance 0.24
Only one of the MHC transmembrane (TM) receptors, HLA-DRA was regulated after 1 h exposure.
Regulation (regulated) of HLA-DRA
15) Confidence 0.04 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.06 Pain Relevance 0
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Regulation (regulated) of HLA-DR in B cells associated with multiple sclerosis
16) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.28 Pain Relevance 0.14
At day 5, U-251 tumor cell lysate was added to the generated immature DCs and by day 6, cell started exhibiting morphological changes that were accompanied with the further changes in the expression of DCs' phenotypical markers such as CD83, CD86, HLA-DR (Figure 1, Supplemental material, Table S1).
Regulation (changes) of HLA-DR in CD86 associated with cancer
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.50 Pain Relevance 0.10
CD2R is an activation-associated epitope unmasked by a conformational change of the CD2 cell-surface glycoprotein.
Regulation (change) of cell-surface glycoprotein
18) Confidence 0.01 Published 1991 Journal Scand. J. Immunol. Section Abstract Doc Link 1715605 Disease Relevance 0.84 Pain Relevance 0.30
The inhibitory effects of anti-inflammatory drugs (ciclosporin, dexamethasone, diclofenac, dimethylfumarate, hydrocortisone, lactoferrin, 1-alpha,25-dihydroxyvitamin D3) on DC maturation (CD83, CD86, HLA-DR, CXCL8) and polarization (type 1: IL-12p70, TNF-alpha; type 2: IL-10, CCL17) were studied.
Regulation (effects) of HLA-DR in CD86
19) Confidence 0.01 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18028503 Disease Relevance 0 Pain Relevance 0

General Comments

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