INT151342

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Context Info
Confidence 0.20
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.79
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
Plasma 2
follicle 2
pituitary gland 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 18 73.60 Quite High
Dismenorea 1 68.24 Quite High
imagery 3 16.00 Low Low
Bioavailability 1 11.68 Low Low
antagonist 52 5.00 Very Low Very Low Very Low
agonist 42 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 48 96.36 Very High Very High Very High
Polycystic Ovary Syndrome 18 95.24 Very High Very High Very High
Endometriosis (extended) 70 95.04 Very High Very High Very High
Ovarian Cysts 36 82.44 Quite High
Disease 3 81.36 Quite High
Reprotox - General 2 4 77.80 Quite High
Reprotox - General 1 21 74.96 Quite High
Myoma 1 71.76 Quite High
Cyst 14 69.12 Quite High
Aging 52 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Improving ovarian response to FSH stimulation in poor responders
Positive_regulation (Improving) of Positive_regulation (stimulation) of FSH
1) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.19 Pain Relevance 0
The increase in circulating plasma FSH levels appears to be due mainly to reduced secretion of follicular growth and differentiation factors related to transforming growth factor-b that negatively affect the release of FSH from the pituitary gland.
Positive_regulation (due) of Positive_regulation (increase) of FSH in pituitary gland
2) Confidence 0.17 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.32 Pain Relevance 0
Although the most rapid increase in aggregate and individual FSH levels occurred after the age of 45, an increasing level of FSH was observed even in young women.
Positive_regulation (increasing) of Positive_regulation (increasing) of FSH
3) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.36 Pain Relevance 0
Chronic administration of the GnRH analogues nafarelin acetate and leuprolide acetate results in an initial stimulation of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which is followed by a profound decrease in the secretion of LH and FSH.
Positive_regulation (results) of Positive_regulation (stimulation) of follicle-stimulating hormone in follicle
4) Confidence 0.04 Published 1992 Journal Trends Endocrinol. Metab. Section Abstract Doc Link 18407075 Disease Relevance 0.30 Pain Relevance 0.11
Plasma basal concentrations of LH and FSH were low and and did not increase after GnRH stimulation test, while the estradiol level was <37 pmol/l.
Neg (not) Positive_regulation (increase) of Positive_regulation (concentrations) of FSH in Plasma
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 0.63 Pain Relevance 0

General Comments

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