INT151350

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 0.79
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
brain 6
frontal cortex 6
hippocampus 2
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 56 100.00 Very High Very High Very High
Hippocampus 14 99.84 Very High Very High Very High
amygdala 7 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of acute and chronic morphine treatments on the expression of Ca2+/calmodulin dependent protein kinase II (CaMK II) gene in rat brain were investigated using in situ hybridization histochemistry.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CaMK II in brain associated with morphine
1) Confidence 0.62 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.50
Our data showed that repeated, but not single morphine administration, resulted in significant up-regulation of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Regulation (regulation) of Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
2) Confidence 0.45 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.10 Pain Relevance 0.65
Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Regulation (regulates) of Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
3) Confidence 0.45 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.17 Pain Relevance 0.76
Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain.
Regulation (regulates) of Gene_expression (expression) of calmodulin dependent protein kinase II in brain associated with morphine
4) Confidence 0.45 Published 2008 Journal Neurochem. Res. Section Title Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.74
The effects of acute and chronic morphine treatments on the expression of Ca2+/calmodulin dependent protein kinase II (CaMK II) gene in rat brain were investigated using in situ hybridization histochemistry.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of calmodulin dependent protein kinase II in brain associated with morphine
5) Confidence 0.39 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.50
Our data showed that repeated, but not single morphine administration, resulted in significant up-regulation of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Regulation (regulation) of in hippocampus Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
6) Confidence 0.15 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.10 Pain Relevance 0.65
Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Regulation (regulates) of in hippocampus Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
7) Confidence 0.15 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.17 Pain Relevance 0.76

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