INT151358

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 98.62 Very High Very High Very High
Thermal hyperalgesia 15 97.78 Very High Very High Very High
Pain 12 93.12 High High
Spontaneous pain 1 82.00 Quite High
cINOD 3 68.96 Quite High
qutenza 50 52.72 Quite High
dorsal root ganglion 27 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
IPN 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 98.62 Very High Very High Very High
Hyperalgesia 18 97.78 Very High Very High Very High
Pain 12 93.12 High High
Aneurism 2 84.52 Quite High
Atherosclerosis 2 83.44 Quite High
Syndrome 1 83.44 Quite High
Cancer 1 80.08 Quite High
Neurodegenerative Disease 1 78.32 Quite High
Nociception 11 77.68 Quite High
Disease 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented herein demonstrate that TRPV1 is essential for the development of thermal hyperalgesia in vivo induced by two major inflammation-associated prostaglandins, PGE2 and PGI2, and that TRPV1 and EP1 or IP receptors can functionally interact, mainly through a PKC-dependent pathway.
IP Binding (interact) of associated with inflammation and thermal hyperalgesia
1) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.72 Pain Relevance 0.51
However, deletion of mPGES-1 permits rediversion of the PGH2 substrate to other PG synthases and augmented formation of PGI2 and PGD2 mitigates this effect.
PGI2 Binding (formation) of
2) Confidence 0.12 Published 2008 Journal J. Intern. Med. Section Abstract Doc Link 18410593 Disease Relevance 1.29 Pain Relevance 0.54

General Comments

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