INT15136

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 3.02
Pain Relevance 12.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
smooth muscle 4
peripheral nerve 4
dorsal 2
PGE2 2
spinal 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 136 100.00 Very High Very High Very High
qutenza 70 100.00 Very High Very High Very High
antagonist 53 100.00 Very High Very High Very High
Spinal cord 34 100.00 Very High Very High Very High
Pain 26 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
bradykinin 9 100.00 Very High Very High Very High
nociceptor 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 13 100.00 Very High Very High Very High
Osteoporosis 4 99.36 Very High Very High Very High
Ganglion Cysts 32 97.62 Very High Very High Very High
Pain 20 96.36 Very High Very High Very High
Increased Venous Pressure Under Development 50 95.48 Very High Very High Very High
Hypercalcemia 1 93.92 High High
Hypersensitivity 11 90.08 High High
INFLAMMATION 21 89.08 High High
Hypotension 2 88.56 High High
Nociception 11 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Regulation (depend) of in peripheral nerve Positive_regulation (Increased) of calcitonin gene-related peptide in dorsal associated with enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
1) Confidence 0.62 Published 1991 Journal J. Mol. Neurosci. Section Title Doc Link 1715733 Disease Relevance 0.49 Pain Relevance 1.53
Effect of capsaicin on smooth muscles of rat vas deferens: involvement of calcitonin gene-related peptide?
Regulation (Effect) of Positive_regulation (involvement) of calcitonin gene-related peptide in smooth muscles associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.45 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3497262 Disease Relevance 0 Pain Relevance 1.18
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Regulation (depend) of in peripheral nerve Positive_regulation (Increased) of CGRP in dorsal associated with enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
3) Confidence 0.45 Published 1991 Journal J. Mol. Neurosci. Section Title Doc Link 1715733 Disease Relevance 0.49 Pain Relevance 1.53
METHODS: Primary cultures of rat trigeminal ganglia were utilized to investigate the effects of CO(2) on CGRP release stimulated by a depolarizing stimulus (KCl), capsaicin, nitric oxide, and/or protons.
Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (stimulated) of CGRP in trigeminal ganglia
4) Confidence 0.45 Published 2007 Journal Headache Section Body Doc Link 18052948 Disease Relevance 0 Pain Relevance 0
However, several studies have recently shown that these neuronal cell bodies could modulate the afferent stimuli by up-regulating various ion channels and also by increasing the synthesis of neuropeptides like calcitonin gene-related peptide (CGRP).
Regulation (regulating) of Positive_regulation (increasing) of CGRP in neuronal associated with neuropeptide and calcitonin gene-related peptide
5) Confidence 0.45 Published 2010 Journal Indian J. Exp. Biol. Section Abstract Doc Link 20882753 Disease Relevance 0.15 Pain Relevance 0.49
In this study we used the dual opioid and nociceptin/orphanin peptide (NOP) agonist buprenorphine to investigate the relative contributions of opioid and NOP systems in regulating bradykinin-stimulated calcitonin-gene related peptide (CGRP) release from primary cultures of neonatal rat trigeminal neurons.
Regulation (regulating) of Positive_regulation (stimulated) of calcitonin in neurons associated with orphanin, agonist, bradykinin, opioid and buprenorphine
6) Confidence 0.43 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285495 Disease Relevance 0 Pain Relevance 1.19
[Effect of eel calcitonin derivative (elcatonin) in osteoporosis].
Regulation ([Effect) of Positive_regulation (derivative) of calcitonin associated with osteoporosis
7) Confidence 0.41 Published 1983 Journal Nippon Seikeigeka Gakkai Zasshi Section Title Doc Link 6676389 Disease Relevance 0.38 Pain Relevance 0
A total of 20 animals were used for monitoring the effects of the tested drugs on CGRP induced dilation.
Regulation (effects) of Positive_regulation (induced) of CGRP associated with calcitonin gene-related peptide
8) Confidence 0.35 Published 2010 Journal J Headache Pain Section Body Doc Link PMC2995862 Disease Relevance 0.38 Pain Relevance 0.22
Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.
Regulation (Effects) of Positive_regulation (stimulated) of iCGRP in skin associated with qutenza and antagonist
9) Confidence 0.33 Published 2004 Journal Pain Section Title Doc Link 15157689 Disease Relevance 0.16 Pain Relevance 1.24
At these concentrations, responses to capsaicin and CGRP were inhibited by the antagonist CGRP(8-37) but unaffected by the neurokinin-1 receptor antagonist, CP 96,345.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (responses) of CGRP associated with qutenza, antagonist and calcitonin gene-related peptide
10) Confidence 0.29 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9308020 Disease Relevance 0.08 Pain Relevance 1.15
We investigated whether NE also affects stimulus-induced intracutaneous calcitonin gene-related peptide (CGRP) and secondary prostaglandin E2 (PGE2) release.
Spec (whether) Regulation (affects) of Positive_regulation (induced) of calcitonin gene-related peptide in PGE2 associated with calcitonin gene-related peptide
11) Confidence 0.27 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.49
Collectively, the results of this study suggest that activity of endocannabinoids, mediated via CB1-receptors, contributes to both the development and maintenance of opioid tolerance by influencing the opioid-induced increase in spinal CGRP.
Regulation (influencing) of Positive_regulation (increase) of CGRP in spinal associated with endocannabinoid, cannabinoid, tolerance, opioid and calcitonin gene-related peptide
12) Confidence 0.23 Published 2007 Journal Neuroscience Section Abstract Doc Link 17395382 Disease Relevance 0.23 Pain Relevance 1.96
We used imaging to study the effects of CGRP-receptor activation on binding of ET-1 to arterial smooth muscle ETA-receptors.
Regulation (effects) of Positive_regulation (activation) of CGRP in smooth muscle associated with imagery and calcitonin gene-related peptide
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.59
Immunohistochemical studies show that TRPV1 in DRG neuronal cell bodies and peripheral terminals are preserved, suggesting that sensory efferent functions such as TRPV1-mediated CGRP and SP release at the peripheral nerve terminals will not be affected.
Neg (not) Regulation (affected) of Positive_regulation (mediated) of CGRP in peripheral nerve associated with dorsal root ganglion
14) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.65 Pain Relevance 0.59

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