INT151387

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 4.00
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav3) plasma membrane organization (Cav3) plasma membrane (Cav3)
enzyme binding (Cav3) protein complex (Cav3) cytoplasm (Cav3)
Anatomy Link Frequency
neuronal 1
colon 1
skeletal muscle 1
pore 1
fibroblasts 1
Cav3 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.3 2 100.00 Very High Very High Very High
Opioid 30 99.64 Very High Very High Very High
Pain 7 99.52 Very High Very High Very High
narcan 18 99.06 Very High Very High Very High
Spinal nerve ligature 1 98.94 Very High Very High Very High
Neuropathic pain 3 98.32 Very High Very High Very High
ischemia 6 97.28 Very High Very High Very High
Calcium channel 28 97.16 Very High Very High Very High
antagonist 16 95.68 Very High Very High Very High
MU agonist 6 93.80 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 43 99.72 Very High Very High Very High
Pain 6 99.52 Very High Very High Very High
Neuropathic Pain 5 98.32 Very High Very High Very High
Carcinoma 2 98.28 Very High Very High Very High
Coronary Artery Disease 7 97.72 Very High Very High Very High
Adenoma 3 97.68 Very High Very High Very High
Injury 7 97.32 Very High Very High Very High
Adenocarcinoma 5 94.28 High High
Cancer 58 90.12 High High
Obesity 24 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a ?
Gene_expression (overexpressing) of Cav-3 associated with targeted disruption, coronary artery disease and ischemia
1) Confidence 0.78 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.35 Pain Relevance 0.63
Opioid-induced preconditioning is dependent on caveolin-3 expression.
Gene_expression (expression) of caveolin-3 associated with opioid
2) Confidence 0.78 Published 2010 Journal Anesth. Analg. Section Title Doc Link 20736437 Disease Relevance 0.36 Pain Relevance 0.74
Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.
Gene_expression (overexpressing) of Cav-3 associated with opioid
3) Confidence 0.67 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.34 Pain Relevance 0.69
Cav-3 overexpressing mice showed innate protection from I/R compared with controls that was abolished by naloxone.
Gene_expression (overexpressing) of Cav-3 associated with narcan
4) Confidence 0.67 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.38 Pain Relevance 0.71
Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.
Gene_expression (expression) of Cav-3 associated with opioid
5) Confidence 0.67 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.35 Pain Relevance 0.70
Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a ?
Gene_expression (overexpressing) of Cav-3 associated with targeted disruption, coronary artery disease and ischemia
6) Confidence 0.67 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.35 Pain Relevance 0.63
To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels.
Neg (lacking) Gene_expression (lacking) of CaV3 in pore associated with pain, spinal nerve ligature and neuropathic pain
7) Confidence 0.65 Published 2008 Journal Mol. Cells Section Abstract Doc Link 18414012 Disease Relevance 0.51 Pain Relevance 0.75
PTRF-CAVIN protein was completely absent from fibroblasts and skeletal muscle, whereas the caveolin-1 and caveolin-3 abundance was unchanged (Figure 4D and 4G).
Gene_expression (abundance) of caveolin-3 in skeletal muscle
8) Confidence 0.62 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.26 Pain Relevance 0
We found that, in both conditions, myotubularin is distributed in the cytosolic S3 fraction, containing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and in the membrane P3 fraction, containing caveolin 3 (which is associated with sarcolemmal caveolae) (Fig. 5D).
Gene_expression (containing) of caveolin 3
9) Confidence 0.52 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.11 Pain Relevance 0
Overexpression of the mRNA of neuronal Na+ channel, Nav1.3, and T-type Ca2+ channel, Cav3.2, may result from a feedback mechanism compensating for the larger conduction deficit of mice with a severe phenotype.
Gene_expression (Overexpression) of Cav3 in neuronal associated with nav1.3
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.19 Pain Relevance 0.17
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Neg (not) Gene_expression (expressing) of Cav3 in oocytes associated with calcium channel
11) Confidence 0.30 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13
The cDNAs for the Cav3.2 (accession number AF051946), Cav2.3 (L27745), ?
Gene_expression (cDNAs) of Cav3
12) Confidence 0.30 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.03
PTRF-CAVIN protein was completely absent from fibroblasts and skeletal muscle, whereas the caveolin-1 and caveolin-3 abundance was unchanged (Figure 4D and 4G).
Gene_expression (abundance) of caveolin-3 in fibroblasts
13) Confidence 0.21 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.26 Pain Relevance 0
Caveolin-3 is not expressed in the colon and is restricted to muscular tissue (Tang et al. 1996).
Neg (not) Gene_expression (expressed) of Caveolin-3 in colon
14) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.38 Pain Relevance 0
While in most cells, Ca2+ channel opening is a rare and brief event, the sustained used of Cav 1.3 Ca2+ channels by SN DA-cells results in a large Ca2+ influx which requires a high metabolic cost to be handled.
Gene_expression (channels) of Cav 1.3
15) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0 Pain Relevance 0.11

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