INT151400

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.96
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (JAG1) structural molecule activity (JAG1) plasma membrane (JAG1)
Anatomy Link Frequency
Notch 3
lymphocytes 2
gum 1
fibroblast 1
trachea 1
JAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 9 98.32 Very High Very High Very High
cytokine 15 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Sicca syndrome 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 95 100.00 Very High Very High Very High
Cancer 274 98.04 Very High Very High Very High
Laryngeal Edema 1 97.60 Very High Very High Very High
Skin Cancer 136 97.46 Very High Very High Very High
Kidney Stones 19 96.88 Very High Very High Very High
Reprotox - General 3 3 95.68 Very High Very High Very High
Syndrome 6 93.24 High High
Hypotension 1 92.88 High High
Thyroid Neoplasm 410 92.72 High High
Acid Reflux 1 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe a successful case of nasal intubation with a combination of AWS and GEB (gum elastic bougie).
AWS Binding (combination) of in gum associated with alagille syndrome
1) Confidence 0.37 Published 2008 Journal Masui Section Abstract Doc Link 18416204 Disease Relevance 0.33 Pain Relevance 0.08
As the patient was scheduled to be ventilated overnight after the operation in the intensive care unit, nasal intubation with a combination of AWS and GEB was planed.
AWS Binding (combination) of in nasal associated with alagille syndrome
2) Confidence 0.37 Published 2008 Journal Masui Section Abstract Doc Link 18416204 Disease Relevance 0.35 Pain Relevance 0.10
Six genes were chosen to confirm the temporal expression analysis: fibroblast growth factor 13 (Fgf13) mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), trafficking protein, kinesin binding 2 (Trak2), Jagged 1 (Jag1), serine/threonine kinase 3 (Stk3), and kruppel-like factor 9 (Klf9).


Jagged 1 Binding (binding) of in fibroblast
3) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
However, glottis was not confirmed even with AWS in the oral cavity, and we could not intubate with AWS.
AWS Neg (not) Binding (intubate) of in oral cavity associated with alagille syndrome
4) Confidence 0.32 Published 2009 Journal Masui Section Abstract Doc Link 19928514 Disease Relevance 0.38 Pain Relevance 0.09
The rate of successful intubations on the first attempt was higher with the Pentax-AWS than the Macintosh laryngoscope (P < 0.001).
Pentax-AWS Binding (higher) of
5) Confidence 0.26 Published 2009 Journal J Clin Anesth Section Body Doc Link 19502032 Disease Relevance 0.06 Pain Relevance 0
The patient's trachea was intubated with the Pentax-AWS by an anesthesiologist positioned at the patient's right and facing her.
Pentax-AWS Binding (intubated) of in trachea associated with alagille syndrome
6) Confidence 0.23 Published 2009 Journal J Anesth Section Abstract Doc Link 19234847 Disease Relevance 1.20 Pain Relevance 0.07
Finally, Köttgen et al [14] reported suggestive association between eGFRcrea and variants at JAG1 (GeneID: 182); we did not replicate this finding in our SCr scan (for rs6040055-T: effect?
JAG1 Binding (association) of
7) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.49 Pain Relevance 0
Although useful for difficult airway management, tracheal intubation with the AWS may be difficult when used in patients with a narrow oral cavity or small tracheal tube.
AWS Binding (intubation) of in tube associated with alagille syndrome
8) Confidence 0.12 Published 2009 Journal Masui Section Abstract Doc Link 19860233 Disease Relevance 0.62 Pain Relevance 0.06
Instead, post-vaccination PBMC proliferated approximately 10-fold more than pre-vaccination lymphocytes in response to DC/Apo-Nec#1 cells, demonstrating that after vaccination with DC/Apo-Nec, lymphocyte clones recognizing Ags shared by the Apo-Nec mixture and the patient's tumor cells had expanded.


Ags Binding (recognizing) of in lymphocytes associated with alagille syndrome and cancer
9) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.72 Pain Relevance 0
In the case of patient #1, an autologous melanoma cell line was established, allowing us to analyze if lymphocytes were primed by DC/Apo-Nec vaccination (allogeneic cells) and recognized autologous Ags.
Ags Binding (recognized) of in lymphocytes associated with alagille syndrome and skin cancer
10) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.86 Pain Relevance 0
We have also used the tetramer binding analysis to quantify CD8+T cells recognizing the same two Ags.
Ags Binding (recognizing) of in T cells associated with alagille syndrome
11) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.49 Pain Relevance 0
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
Jagged1 Binding (Binding) of in Notch
12) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.79 Pain Relevance 0
Binding of any one of the Notch ligands (e.g., DLL-1 or JAG-1) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
JAG-1 Binding (Binding) of in Notch
13) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.88 Pain Relevance 0
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
JAG-1 Binding (Binding) of in Notch
14) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.79 Pain Relevance 0

General Comments

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