INT151421

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.61
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 4
blood 2
testis 2
skeletal muscle 2
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 94 100.00 Very High Very High Very High
ischemia 229 99.36 Very High Very High Very High
Glutamate 19 98.84 Very High Very High Very High
Dopamine 18 98.50 Very High Very High Very High
Inflammation 25 95.56 Very High Very High Very High
monoamine 9 84.80 Quite High
ketamine 7 80.16 Quite High
Calcium channel 1 80.12 Quite High
cytokine 9 73.52 Quite High
Morphine 3 68.04 Quite High
Disease Link Frequency Relevance Heat
Stress 35 99.70 Very High Very High Very High
Cv Unclassified Under Development 173 99.36 Very High Very High Very High
Disorders Of Creatine Metabolism 3 98.84 Very High Very High Very High
Pressure Volume 2 Under Development 14 98.80 Very High Very High Very High
Reperfusion Injury 32 98.60 Very High Very High Very High
Hypertension 32 98.56 Very High Very High Very High
Heat Stroke 114 97.98 Very High Very High Very High
INFLAMMATION 28 95.56 Very High Very High Very High
Pressure And Volume Under Development 16 88.00 High High
Acidosis 2 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The S. leriifolia extracts reversed the increase of MDA levels to a considerable extent, thereby confirming its antioxidant role in I/R.
Negative_regulation (reversed) of Positive_regulation (increase) of MDA
1) Confidence 0.30 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.24 Pain Relevance 0.05
Present study showed that S. lerrifolia extracts suppressed the increase of MDA levels in the rat skeletal muscle and therefore inhibited lipid peroxidation following ischemia-reperfusion injury.
Negative_regulation (suppressed) of Positive_regulation (increase) of MDA in skeletal muscle associated with reperfusion injury and ischemia
2) Confidence 0.22 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.83 Pain Relevance 0.39
In the present study TMZ has inhibited the increase in MDA values of the retinal tissue which has undergone I/R.
Negative_regulation (inhibited) of Positive_regulation (increase) of MDA
3) Confidence 0.12 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0.68 Pain Relevance 0.07
Interestingly, in the present study in which the duration of ischemia was doubled (180 min) compared to the study of Ceylan et al [10], both single and triple applications of 10 min (group 2, group 5) ischemic preconditioning significantly reduced MDA increase in response to ischemia in rat testicular tissue.
Negative_regulation (reduced) of Positive_regulation (increase) of MDA associated with ischemia
4) Confidence 0.07 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.72 Pain Relevance 0.29
CMN markedly reduced the elevated MDA levels, significantly increased the antioxidant enzyme activity and normalized the altered renal morphology in rats treated with APAP.
Negative_regulation (reduced) of Positive_regulation (elevated) of MDA associated with paracetamol
5) Confidence 0.07 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 19345714 Disease Relevance 0.22 Pain Relevance 0.85
Aqueous extract of Embelia ribes reversed the increase of MDA levels to a considerable extent, thereby confirming its antioxidant role in ischemia reperfusion injury.
Negative_regulation (reversed) of Positive_regulation (increase) of MDA associated with ischemia
6) Confidence 0.07 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.69 Pain Relevance 0.13
In guinea-pig lungs, ischemic preconditioning was found to prevent MDA increase, whereas no change could have been observed in rat testis.
Negative_regulation (prevent) of Positive_regulation (increase) of MDA in testis
7) Confidence 0.07 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.47 Pain Relevance 0.20
Indeed, according to our present findings, the heat stroke-induced high levels of DA, 5-HT, glutamate, and hydroxyl radicals in rats' corpus striatum, and the elevated plasma MDA levels can be prevented by acute treatment with the combined agent.
Negative_regulation (prevented) of Positive_regulation (elevated) of MDA in plasma associated with heat stroke, glutamate and dopamine
8) Confidence 0.03 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 1.23 Pain Relevance 0.41
TFR (20, 40 mg/kg) pretreatment decreased I/R-induced IS/AAR, markedly inhibited the increase of MDA content and the activity of CK and LDH, and also significantly inhibited the decline of NO content and the activity of NOS and SOD in serum.
Negative_regulation (inhibited) of Positive_regulation (increase) of MDA associated with disorders of creatine metabolism
9) Confidence 0.03 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.59 Pain Relevance 0.11
Likewise, the increase in the plasma MDA induced by APAP was reduced to 32% by NAC (p<0.01), to 36% by HYTAU (p<0.01), and to 90% by TAU (p<0.001) relative to the control value (Figure 8).


Negative_regulation (reduced) of Positive_regulation (increase) of MDA in plasma associated with paracetamol
10) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.22 Pain Relevance 0.79
This study has thus shown that amlodipine therapy decreased blood pressure, and improved the status of oxidative stress as shown by a decrease in MDA and increase in Na+ K+ ATPase and SOD levels in essential hypertension patients.
Negative_regulation (decrease) of Positive_regulation (increase) of MDA in blood associated with stress, pressure volume 2 under development and hypertension
11) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127225 Disease Relevance 0.73 Pain Relevance 0.04

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