INT151427

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 21.86
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADC) mitochondrion (ADC) small molecule metabolic process (ADC)
lyase activity (ADC) cellular nitrogen compound metabolic process (ADC)
Anatomy Link Frequency
blood 3
amygdala 2
basal ganglia 2
cortex 2
Plasma 1
ADC (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 478 99.90 Very High Very High Very High
amygdala 58 99.68 Very High Very High Very High
ischemia 165 99.36 Very High Very High Very High
imagery 529 98.46 Very High Very High Very High
Hippocampus 47 86.88 High High
Inflammatory response 7 82.20 Quite High
anesthesia 78 81.12 Quite High
Inflammation 77 80.32 Quite High
carpal tunnel syndrome 2 76.68 Quite High
cytokine 97 59.40 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1305 100.00 Very High Very High Very High
Infection 906 100.00 Very High Very High Very High
Disease 164 100.00 Very High Very High Very High
Neurological Disease 61 100.00 Very High Very High Very High
Ketoacidosis 605 99.72 Very High Very High Very High
Viral Meningitis 149 99.44 Very High Very High Very High
Cv Unclassified Under Development 120 99.36 Very High Very High Very High
Pressure Volume 2 Under Development 3 99.00 Very High Very High Very High
Injury 200 98.88 Very High Very High Very High
Systemic Lupus Erythematosus 168 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no statistically significant differences were found for mean ADC values.
Gene_expression (values) of ADC
1) Confidence 0.55 Published 2008 Journal Eur Radiol Section Abstract Doc Link 18418602 Disease Relevance 0.25 Pain Relevance 0.35
Because of the resulting phase dispersion among the three water molecules, the MRI signal is attenuated (RF radio frequency)In biological tissue, diffusion is expressed and quantified by means of an effective or apparent diffusion coefficient (ADC).
Gene_expression (expressed) of ADC associated with imagery
2) Confidence 0.43 Published 2008 Journal Eur Radiol Section Body Doc Link PMC2516183 Disease Relevance 0.05 Pain Relevance 0.15
For all ADC subjects, the CD4 median was 67.5 cells/?
Gene_expression (subjects) of ADC
3) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.13 Pain Relevance 0
CSF infection is importantly influenced by the CSF WBC response, the degree of systemic immunological progression as measured by blood CD4+ T cells, antiretroviral treatment and drug resistance, and the presence of active ADC.
Gene_expression (presence) of ADC in T cells associated with infection
4) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.00 Pain Relevance 0
Since drug resistance is the principal reason for long-term treatment failure, this may have very important implications for the prevention and treatment of CNS HIV infection and ADC.
Gene_expression (infection) of ADC associated with acquired immune deficiency syndrome or hiv infection, central nervous system and infection
5) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.76 Pain Relevance 0.05
The four subjects in the treatment group who presented with active ADC (5002, 4033, 4013, and 4034) showed both clinical improvement and distinct increases in this performance score in response to initiation or change of antiretroviral therapy.
Gene_expression (presented) of ADC
6) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.38 Pain Relevance 0
L (IQR 28.0 – 124.5); for the untreated ADC subgroup, the median was 35 (IQR 14.5 – 67.5) cells/?
Gene_expression (subgroup) of ADC
7) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.13 Pain Relevance 0
Figure 6 shows two of these in which ADC 2-4 (A) and ADC 1-4 (B) were compared to the four groups of untreated neuroasymptomatic subjects.
Gene_expression (compared) of ADC
8) Confidence 0.32 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.18 Pain Relevance 0.18
Another is the difficulty in diagnosis of ADC/HIVE in many patients currently presenting with neurological symptoms and signs within a background context of drug use, psychiatric disorders, homelessness and socioeconomical deprivation which, unfortunately, also frequently reduce access and capacity to adhere to combination antiretroviral therapy (cART), leaving these patients with pre-existing neurological disease particularly vulnerable to progressive HIV disease, including ADC.
Gene_expression (presenting) of ADC associated with neurological disease, acquired immune deficiency syndrome or hiv infection, disease and viral meningitis
9) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.00 Pain Relevance 0.07
Figure 6 shows two of these in which ADC 2-4 (A) and ADC 1-4 (B) were compared to the four groups of untreated neuroasymptomatic subjects.
Gene_expression (compared) of ADC 1-4
10) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.17 Pain Relevance 0.17
The ADC groups had higher CSF WBC counts than the non-ADC group with <50 CD4+ cells, but other HIV+ groups had similar WBC counts without such neopterin increase, which clearly indicates that CSF neopterin in ADC was not caused by the CSF pleocytosis.
Gene_expression (groups) of ADC associated with leukocytosis and acquired immune deficiency syndrome or hiv infection
11) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.62 Pain Relevance 0.03
Blood neopterin was higher in the ADC 2-4 than in the NA with CD4+ cell counts ?
Gene_expression (higher) of ADC in Blood
12) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.03 Pain Relevance 0.16
This increase in blood neopterin also paralleled the plasma HIV RNA levels (p < 0.0001, r = 0.433) (Figure 2D)

CSF Neopterin in ADC

Gene_expression (paralleled) of ADC in blood associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.70 Pain Relevance 0.07
The ADC groups had higher CSF WBC counts than the non-ADC group with <50 CD4+ cells, but other HIV+ groups had similar WBC counts without such neopterin increase, which clearly indicates that CSF neopterin in ADC was not caused by the CSF pleocytosis.
Gene_expression (group) of ADC associated with leukocytosis and acquired immune deficiency syndrome or hiv infection
14) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.58 Pain Relevance 0.03
The average ADC in the amygdala of patients with NP-SLE and SLE (940 × 10?
Gene_expression (The) of ADC in amygdala associated with systemic lupus erythematosus and amygdala
15) Confidence 0.15 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 0.93 Pain Relevance 0.43
The average ADC in the amygdala of patients with NP-SLE and SLE (940 × 10?
Gene_expression (average) of ADC in amygdala associated with systemic lupus erythematosus and amygdala
16) Confidence 0.15 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 0.92 Pain Relevance 0.43
Mean ADC values in the basal ganglia for the piglets as a group at baseline and after 7 hours were 101.37±12.44×10?
Gene_expression (values) of ADC in basal ganglia
17) Confidence 0.10 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.29 Pain Relevance 0.08
A previous study has shown that ADC reduction during HI in a piglet model is reversible after 30 min (9).
Gene_expression (reduction) of ADC
18) Confidence 0.10 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.70 Pain Relevance 0.26
The mean ADC values obtained in this study at baseline are comparable with previously reported values, with a baseline ADC value of 101±7×10?
Gene_expression (values) of ADC
19) Confidence 0.10 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.25 Pain Relevance 0.16
There was a strong correlation between reduced ADC value after 7 hours and ischemic injury as determined by histology (Rs=0.905, P=0.01).
Gene_expression (value) of ADC associated with injury
20) Confidence 0.10 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.23 Pain Relevance 0.07

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