INT15143

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 1.00
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.56
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
NALM-1 2
epithelium 2
thymocyte 1
body 1
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 39 100.00 Very High Very High Very High
substance P 79 99.96 Very High Very High Very High
Opioid 3 97.88 Very High Very High Very High
bradykinin 6 97.80 Very High Very High Very High
Neuropeptide 10 97.72 Very High Very High Very High
Inflammation 23 93.48 High High
cytokine 22 92.40 High High
metalloproteinase 18 90.04 High High
opioid receptor 1 85.84 High High
calcitonin gene related peptide 1 85.04 High High
Disease Link Frequency Relevance Heat
Prostate Cancer 87 99.20 Very High Very High Very High
Natriuresis 1 98.52 Very High Very High Very High
Leukemia 2 97.32 Very High Very High Very High
Gallbladder Disease 14 96.88 Very High Very High Very High
Cough 57 94.64 High High
Metastasis 33 94.04 High High
INFLAMMATION 23 93.48 High High
Chronic Sinusitis 2 90.40 High High
Asthma 25 86.88 High High
Pressure And Volume Under Development 1 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among all the enzymes involve din enkephalin degradation "enkephalinase", cleaving the Gly3-Phe4 amide bond, is considered for its specificity with endogenous enkephalins and their receptors.
Protein_catabolism (degradation) of enkephalinase associated with enkephalin
1) Confidence 1.00 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3544724 Disease Relevance 0 Pain Relevance 0.25
In various tissues, enkephalins are partly degraded by a membrane metallo-endopeptidase, enkephalinase (EC 3.4.24.11). 2.
Protein_catabolism (degraded) of enkephalinase associated with enkephalin
2) Confidence 0.99 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2758762 Disease Relevance 0.39 Pain Relevance 0.38
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Protein_catabolism (degrading) of NEP in epithelium associated with neuropeptide and substance p
3) Confidence 0.87 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.56 Pain Relevance 0.40
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Protein_catabolism (degrading) of neutral endopeptidase in epithelium associated with neuropeptide and substance p
4) Confidence 0.87 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.56 Pain Relevance 0.40
Endopeptidase 24.11 (EP 24.11; also called neutral endopeptidase, enkephalinase, CALLA, or CD10) and endopeptidase 24.15 (EP 24.15) are widely distributed neutral metalloendopeptidases that degrade a number of bioactive peptides including substance P, bradykinin, neurotensin, and chemotactic peptides.
Protein_catabolism (degrade) of CD10 associated with bradykinin and substance p
5) Confidence 0.87 Published 1994-1995 Journal Enzyme Protein Section Abstract Doc Link 8589801 Disease Relevance 0 Pain Relevance 0.10
Endopeptidase 24.11 (EP 24.11; also called neutral endopeptidase, enkephalinase, CALLA, or CD10) and endopeptidase 24.15 (EP 24.15) are widely distributed neutral metalloendopeptidases that degrade a number of bioactive peptides including substance P, bradykinin, neurotensin, and chemotactic peptides.
Protein_catabolism (degrade) of enkephalinase associated with bradykinin and substance p
6) Confidence 0.87 Published 1994-1995 Journal Enzyme Protein Section Abstract Doc Link 8589801 Disease Relevance 0 Pain Relevance 0.10
NALM-1 cells (a cell line derived from human pre-B leukemia) were exposed to the opioid pentapeptide methionine-enkephalin (Met-enkephalin) and/or to thiorphan, an inhibitor of the enzyme that degrades the enkephalins (membrane endopeptidase EC 3.4.24.11, CALLA, the CD10 marker).
Protein_catabolism (degrades) of CD10 in NALM-1 associated with leukemia, enkephalin and opioid
7) Confidence 0.86 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12757739 Disease Relevance 0.10 Pain Relevance 0.68
NALM-1 cells (a cell line derived from human pre-B leukemia) were exposed to the opioid pentapeptide methionine-enkephalin (Met-enkephalin) and/or to thiorphan, an inhibitor of the enzyme that degrades the enkephalins (membrane endopeptidase EC 3.4.24.11, CALLA, the CD10 marker).
Protein_catabolism (degrades) of CALLA in NALM-1 associated with leukemia, enkephalin and opioid
8) Confidence 0.86 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12757739 Disease Relevance 0.10 Pain Relevance 0.68
In various tissues, enkephalins are partly degraded by a membrane metallo-endopeptidase, enkephalinase (EC 3.4.24.11). 2.
Protein_catabolism (degraded) of metallo-endopeptidase associated with enkephalin
9) Confidence 0.86 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2758762 Disease Relevance 0.38 Pain Relevance 0.38
Enkephalins are short lived peptides which are rapidly cleaved by 2 membrane peptidases: an enkephalinase and a carboxypeptidase.
Protein_catabolism (cleaved) of enkephalinase associated with enkephalin
10) Confidence 0.66 Published 1988 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 3220232 Disease Relevance 0 Pain Relevance 0.38
Recently, Pierart et al. reported that NEP degraded purified interleukin-1 (IL-1) using thymocyte proliferation assay.
Protein_catabolism (degraded) of NEP in thymocyte
11) Confidence 0.55 Published 1991 Journal Immunol. Lett. Section Abstract Doc Link 1715845 Disease Relevance 0.15 Pain Relevance 0.24
Membrane metalloendopeptidase (MMEP; EC 3.4.24.11; enkephalinase) catalyzes the degradation of endothelins, enkephalins, atrial natriuretic factor, substance P, and other small bioactive peptides.
Protein_catabolism (degradation) of enkephalinase associated with natriuresis, enkephalin and substance p
12) Confidence 0.54 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1744100 Disease Relevance 0.10 Pain Relevance 0.15
Thus, the aims of the present study were to determine the presence of tachykinins, tachykinin receptors and tachykinins degrading enzyme neutral endopeptidase (NEP) mRNAs, and hHK-1 protein in human bronchial tissues, and to characterize the effects of hHK-1, EKA/B (common C-terminal decapeptide of EKA and EKB [6,38]), EKC and EKD in human and guinea-pig isolated airways.
Protein_catabolism (degrading) of NEP
13) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.39 Pain Relevance 0.31
NEP degrades a variety of bioactive peptides including endothelin, which has been implicated in the growth of hormone refractory prostate cancer.
Protein_catabolism (degrades) of NEP associated with prostate cancer
14) Confidence 0.22 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.81 Pain Relevance 0.49
NEP degrades, and so regulates, the duration of action of many small neuropeptides [34].
Protein_catabolism (degrades) of NEP associated with neuropeptide
15) Confidence 0.17 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.51 Pain Relevance 0.61
Thereby liraglutide is fully metabolized in the body by sequential cleavage of small peptide fragments and amino acids, which involves DPP-IV and neutral endopeptidase (NEP), and clearance of liraglutide is suggested to take place by multiple organ/tissues (EMEA/379172/2009).
Protein_catabolism (cleavage) of neutral endopeptidase in body
16) Confidence 0.07 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2997321 Disease Relevance 0.53 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox