INT151434

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 30
Disease Relevance 18.34
Pain Relevance 16.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neurons 5
neuronal 2
spinal 2
nerve 2
sensory neurons 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1570 100.00 Very High Very High Very High
Demyelination 459 99.76 Very High Very High Very High
Peripheral nerve injury 58 99.66 Very High Very High Very High
Pain 237 99.14 Very High Very High Very High
dorsal root ganglion 506 99.04 Very High Very High Very High
Eae 180 98.80 Very High Very High Very High
imagery 137 98.80 Very High Very High Very High
Neuropathic pain 382 98.56 Very High Very High Very High
antagonist 440 98.40 Very High Very High Very High
Calcium channel 10 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 648 99.98 Very High Very High Very High
Demyelinating Disease 480 99.76 Very High Very High Very High
Nervous System Injury 372 99.66 Very High Very High Very High
Pain 334 99.14 Very High Very High Very High
Ganglion Cysts 517 99.04 Very High Very High Very High
Neuropathic Pain 525 98.56 Very High Very High Very High
Inflammatory Pain 29 98.20 Very High Very High Very High
Rheumatoid Arthritis 219 98.18 Very High Very High Very High
Bordatella Infection 4 96.56 Very High Very High Very High
Nociception 251 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanism underlying calcium mobilization evoked by CCR2 activation in DRG neurons
Positive_regulation (activation) of CCR2 in neurons
1) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.15 Pain Relevance 0.07
Therefore, preventing the activation of CCR2 might provide a fruitful strategy for treating pain.
Positive_regulation (activation) of CCR2 associated with pain
2) Confidence 0.63 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18419759 Disease Relevance 0.69 Pain Relevance 1.07
These pronociceptive effects of CCL2 are completely prevented by the selective CCR2 antagonist (INCB3344), indicating that CCL2-induced pain facilitation is elicited via direct spinal activation of CCR2 receptor.
Positive_regulation (activation) of CCR2 receptor in spinal associated with pain and antagonist
3) Confidence 0.63 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18419759 Disease Relevance 0.61 Pain Relevance 1.09
We previously reported upregulation of CCR2 chemokine receptor signaling in association with chronic compression of the DRG [8].
Positive_regulation (upregulation) of CCR2 chemokine receptor associated with chemokine
4) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.89 Pain Relevance 0.63
CCR2, CXCR4, CXCR3 and CCR5 upregulation in L4–L5 DRG after unilateral LPC-induced nerve demyelination
Positive_regulation (upregulation) of CCR2 in nerve associated with demyelination
5) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.97 Pain Relevance 0.70
The upregulation of MCP-1 and the CCR2 chemokine receptor observed in association with focal nerve demyelination is similar to the pattern we previously observed using a spinal stenosis model of neuropathic pain [8].
Positive_regulation (upregulation) of CCR2 chemokine receptor in spinal associated with chemokine, demyelination, neuropathic pain and spinal stenosis
6) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 1.05
To investigate whether chemokine receptors, in addition to CCR2, are upregulated following focal nerve demyelination, in situ hybridization studies were performed on injured rat DRG tissue sections.
Spec (whether) Positive_regulation (upregulated) of CCR2 in nerve associated with chemokine and demyelination
7) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.38 Pain Relevance 0.46
Indeed, following upregulation of CCR2 by sensory neurons in whole DRG derived from animals exhibiting neuropathic pain, application of MCP-1 produces powerful excitation [8].
Positive_regulation (upregulation) of CCR2 in sensory neurons associated with neuropathic pain
8) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.65 Pain Relevance 0.66
As activation of CCR2 receptors in the DRG is probably of considerable importance in the production of pain behavior it is likely that block of these receptors contributes to the antinociceptive effects of the CCR2 antagonist.
Positive_regulation (activation) of CCR2 associated with pain, antagonist and antinociceptive
9) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.42 Pain Relevance 0.90
As such, it is possible that the population of neurons that upregulates CCR2 signaling is particularly linked to the production of neuronal hyperexcitability.
Positive_regulation (upregulates) of CCR2 in neuronal associated with hyperexcitability
10) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.72 Pain Relevance 1.03
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Positive_regulation (upregulated) of CCR2 in neurons associated with demyelination
11) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.91
Together with behavioral changes, pronounced increases in MCP1/CCR2, but not SDF1/CXCR4 chemokine signaling events were observed.
Positive_regulation (increases) of CCR2 associated with chemokine
12) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.56 Pain Relevance 0.23
We observed that after gp120/hCD4 treatment, MCP1/CCR2 signaling events were upregulated in neurons of the affected DRG.
Positive_regulation (upregulated) of CCR2 in neurons associated with dorsal root ganglion
13) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.11 Pain Relevance 0.57
These results have important implications in the present pain model, where an antagonist to the CXCR4 receptor was effective in completely attenuating the pain behavior despite the fact that functional CCR2 receptors were simultaneously upregulated.
Positive_regulation (upregulated) of CCR2 associated with pain and antagonist
14) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.63 Pain Relevance 0.40
Using immunohistochemical studies, we demonstrated that MCP1 and CCR2 were upregulated by primary sensory neurons in lumbar ganglia by post-operative day (POD) 14.
Positive_regulation (upregulated) of CCR2 in ganglia
15) Confidence 0.60 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734548 Disease Relevance 1.00 Pain Relevance 0.50
This is because along with a previous study, where the importance of CXCR4/SDF1 signaling in a NRTI-associated neuropathic pain model was demonstrated, other studies had shown that peripheral nerve injury resulted in the upregulation of CCR2 and its ligand MCP1 in DRG neurons [7,22,24,36-38].
Positive_regulation (upregulation) of CCR2 in neurons associated with dorsal root ganglion, nervous system injury, neuropathic pain and peripheral nerve injury
16) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.16 Pain Relevance 0.53
Each of these injuries produced the same significant increase in CCR2 protein in the DRG, as assessed by Western blot analyses.
Positive_regulation (increase) of CCR2 protein in DRG associated with injury
17) Confidence 0.49 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.86 Pain Relevance 0.40
M U73122 before (5 min), during and after CCL2 application, the evoked calcium mobilization was significantly blocked (p < 0.05, n = 6 cells, Figure 3G) suggesting that activation of the PLC/IP3 pathways is necessary for the CCR2 function in DRG neurons from CCI rats.


Positive_regulation (necessary) of CCR2 in neurons associated with eae
18) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.82 Pain Relevance 0.44
Additionally, CCR2 activation evokes excitatory Ca2+ rises in DRG cells [4,24] but the underlying mechanism is still poorly understood.
Positive_regulation (activation) of CCR2
19) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.34 Pain Relevance 0.39
A peripheral site of action was proposed based on the predominantly peripheral expression and activation of CCR2 in a demyelination injury model of neuropathic pain [17].
Positive_regulation (activation) of CCR2 associated with demyelination, injury and neuropathic pain
20) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.49 Pain Relevance 1.03

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