INT151436

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.81
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neurons 2
Spinal 1
spinal cord 1
astrocytes 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 78 100.00 Very High Very High Very High
Pain 20 99.84 Very High Very High Very High
nociceptor 5 98.04 Very High Very High Very High
chemokine 78 96.92 Very High Very High Very High
Spinal cord 76 96.88 Very High Very High Very High
hyperexcitability 3 96.64 Very High Very High Very High
antinociception 8 95.04 Very High Very High Very High
qutenza 13 93.36 High High
Lasting pain 3 92.44 High High
Neuropathic pain 59 91.04 High High
Disease Link Frequency Relevance Heat
Pain 24 99.84 Very High Very High Very High
Status Epilepticus 212 96.92 Very High Very High Very High
Neuropathic Pain 106 91.04 High High
Hyperalgesia 58 82.40 Quite High
Peripheral Neuropathy 5 81.84 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 80.44 Quite High
Hypersensitivity 8 72.28 Quite High
Injury 95 68.44 Quite High
Nervous System Injury 20 67.40 Quite High
Ganglion Cysts 43 65.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, a novel selective pharmacological tool, AZ889, was used to characterize the CCL2/CCR2 effects on pain processing cells and to show that these effects, particularly in the spinal cord, could account for AZ889-mediated antinociception.
Regulation (effects) of CCR2 in spinal cord associated with antinociception, pain and spinal cord
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 1.15 Pain Relevance 0.99
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats.
Regulation (effective) of CCR2 receptor in Spinal associated with antagonist
2) Confidence 0.41 Published 2008 Journal J. Neurochem. Section Title Doc Link 18419759 Disease Relevance 0.51 Pain Relevance 0.89
As such, it is quite possible that the population of CCR2 or CXCR4 positive neurons is directly linked to the production of chronic neuronal hyperexcitability.
Spec (possible) Regulation (population) of CCR2 in neurons associated with hyperexcitability
3) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.24 Pain Relevance 0.37
CCR2 antagonist AZ889, dissolved in dimethyl sulfoxide and diluted in PBS to its final concentration, was applied through the bath perfusion system.
Regulation (diluted) of CCR2 associated with antagonist
4) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0 Pain Relevance 0.41
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Regulation (immunoreactivity) of CCR2 in neurons associated with status epilepticus
5) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.45 Pain Relevance 0.08
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Regulation (immunoreactivity) of CCR2 in astrocytes associated with status epilepticus
6) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

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