INT15144

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Context Info
Confidence 0.92
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.67
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
thymocyte 2
cartilage 1
fibroblast 1
connective tissue 1
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 152 99.12 Very High Very High Very High
Neuropeptide 4 97.48 Very High Very High Very High
metalloproteinase 36 96.92 Very High Very High Very High
Inflammation 225 95.84 Very High Very High Very High
rheumatoid arthritis 177 93.20 High High
Osteoarthritis 74 92.00 High High
pulpitis 1 91.80 High High
Sciatica 14 90.08 High High
backache 4 87.04 High High
Arthritis 84 83.04 Quite High
Disease Link Frequency Relevance Heat
Necrosis 15 99.70 Very High Very High Very High
Cancer 19 99.52 Very High Very High Very High
INFLAMMATION 243 95.84 Very High Very High Very High
Rheumatoid Arthritis 180 93.20 High High
Osteoarthritis 75 92.00 High High
Pulpitis 1 91.80 High High
Arthritis 83 90.48 High High
Nerve Root Compression 14 90.08 High High
Disease 77 90.00 High High
Low Back Pain 10 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, Pierart et al. reported that NEP degraded purified interleukin-1 (IL-1) using thymocyte proliferation assay.
Protein_catabolism (degraded) of interleukin-1 in thymocyte
1) Confidence 0.92 Published 1991 Journal Immunol. Lett. Section Abstract Doc Link 1715845 Disease Relevance 0.15 Pain Relevance 0.25
The aim of this study was to investigate whether polymorphisms in the IL-1?
Spec (whether) Protein_catabolism (polymorphisms) of IL-1
2) Confidence 0.86 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.79 Pain Relevance 0.20
Recently, Pierart et al. reported that NEP degraded purified interleukin-1 (IL-1) using thymocyte proliferation assay.
Protein_catabolism (degraded) of IL-1 in thymocyte
3) Confidence 0.82 Published 1991 Journal Immunol. Lett. Section Abstract Doc Link 1715845 Disease Relevance 0.15 Pain Relevance 0.25
The degradative effects of interleukin-1 (IL-1) on the extracellular matrix of connective tissue are mediated primarily by metalloproteinases and prostaglandins.
Protein_catabolism (degradative) of IL-1 in connective tissue associated with metalloproteinase
4) Confidence 0.71 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.08 Pain Relevance 0.17
Demonstrating that inhibitors of IL-1Ra almost completely eliminate matrix degrading activity places IL-1 as a key regulator of matrix degradation in DIVD.
Protein_catabolism (degradation) of IL-1
5) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.24 Pain Relevance 0.18
This study has built on previous, largely observational data implicating IL-1 in the matrix degradation that characterizes degeneration of the IVD.
Protein_catabolism (degradation) of IL-1
6) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.04
activators prevents IL-1-induced proteoglycan degradation [13].
Protein_catabolism (degradation) of IL-1
7) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.46 Pain Relevance 0.15
This suggests that the activation of NO and MMP pathways by IL-1?
Protein_catabolism (pathways) of IL-1
8) Confidence 0.32 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.15 Pain Relevance 0.03
The effects of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and transforming growth factor-beta1 on pulp fibroblast mediated collagen degradation.
Protein_catabolism (degradation) of interleukin-1beta in fibroblast associated with necrosis, cancer and cytokine
9) Confidence 0.28 Published 2006 Journal J Endod Section Title Doc Link 16934628 Disease Relevance 0.29 Pain Relevance 0.50
Unlike IL-4, IL-10 can also enhance degradation of the mRNA for IL-1 and TNF-?
Protein_catabolism (degradation) of IL-1
10) Confidence 0.18 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.86 Pain Relevance 0.31
Unlike IL-4, IL-10 can also enhance degradation of the mRNA for IL-1 and TNF-?
Protein_catabolism (degradation) of IL-1
11) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.82 Pain Relevance 0.37
Epigallocatechin-3 galate inhibits IL-1–induced proteoglycan release and type 2 collagen degradation in cartilage explants.[44] In human in vitro models, it also suppresses IL-1b and attenuates activation of the transcription factor NF-kB.
Protein_catabolism (degradation) of IL-1 in cartilage
12) Confidence 0.07 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.69 Pain Relevance 0.15

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