INT151441

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 10.21
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cell 10
thymocytes 6
NK cell 2
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 4 100.00 Very High Very High Very High
rheumatoid arthritis 319 99.12 Very High Very High Very High
Inflammation 322 97.84 Very High Very High Very High
Osteoarthritis 50 97.52 Very High Very High Very High
cytokine 355 95.96 Very High Very High Very High
chemokine 72 93.44 High High
Inflammatory response 18 92.76 High High
Arthritis 150 89.88 High High
Multiple sclerosis 126 79.52 Quite High
Peripheral nervous system 1 71.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 27 100.00 Very High Very High Very High
Neuritis 3 100.00 Very High Very High Very High
Lymphatic System Cancer 98 99.82 Very High Very High Very High
Rheumatoid Arthritis 323 99.12 Very High Very High Very High
Autoimmune Disease 115 98.92 Very High Very High Very High
INFLAMMATION 356 97.84 Very High Very High Very High
Osteoarthritis 50 97.52 Very High Very High Very High
Disease 336 96.16 Very High Very High Very High
Asthma 104 94.72 High High
Ankylosing Spondylitis 3 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TCR in T cell
1) Confidence 0.65 Published 2008 Journal Ophthalmic Res. Section Body Doc Link 18421237 Disease Relevance 0.19 Pain Relevance 0
Useful TCR interactions will result in positive selection of the cell, upregulation of TCR and CD69 surface expression, and lineage commitment of CD4 SP and CD8 SP thymocytes.
Positive_regulation (upregulation) of Gene_expression (expression) of TCR in thymocytes
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.08 Pain Relevance 0
These results show that bacterial Sags upregulate the expression of Fas and Fas-L on lymphoma T cells expressing the appropriate TCR V?
Positive_regulation (appropriate) of Gene_expression (expressing) of TCR in T cells associated with lymphatic system cancer
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.90 Pain Relevance 0
Thymic epithelial cells play a critical role in the positive selection of developing thymocytes as rearranged TCR?
Positive_regulation (rearranged) of Gene_expression (rearranged) of TCR in thymocytes
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0.04
rearrangement, and test the newly generated TCR?
Positive_regulation (generated) of Gene_expression (generated) of TCR
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0
Thymic epithelial cells play a critical role in the positive selection of developing thymocytes as rearranged TCR?
Positive_regulation (selection) of Gene_expression (rearranged) of TCR in thymocytes
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0.04
Systemic autoreactivity causes peripheral neuritis in TCR transgenic mice
Positive_regulation (causes) of Gene_expression (transgenic mice) of TCR associated with targeted disruption and neuritis
7) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.76 Pain Relevance 0.58
expression because the proportions of TCR?
Positive_regulation (because) of Gene_expression (proportions) of TCR
8) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.14 Pain Relevance 0.04
Furthermore, transendothelial migration experiments demonstrated an enhanced propensity for circulating TCR?
Positive_regulation (enhanced) of Gene_expression (propensity) of TCR
9) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.37 Pain Relevance 0.22
Furthermore, transendothelial migration experiments demonstrated an enhanced propensity for circulating TCR?
Positive_regulation (circulating) of Gene_expression (propensity) of TCR
10) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.37 Pain Relevance 0.22
(hereafter, TCR?
Positive_regulation (hereafter) of Gene_expression (hereafter) of TCR
11) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.80 Pain Relevance 0.11
We documented considerable variability in expression of PB TCR?
Positive_regulation (variability) of Gene_expression (expression) of TCR
12) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.24 Pain Relevance 0.09
mediates signaling and is also necessary for surface expression of the TCR.
Positive_regulation (necessary) of Gene_expression (expression) of TCR
13) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.06 Pain Relevance 0.03
Since these cells express not only the T cell receptor (TCR) but also the NK cell receptors NK1.1 or Ly49 in mice and CD161 in humans, current research defines these cells as a unique and evolutionally conserved group of T cells.
Positive_regulation (receptors) of Gene_expression (express) of TCR in NK cell
14) Confidence 0.08 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.64 Pain Relevance 0.16
Surprisingly, when the ability of the public TCR to recognize these NP366 peptide variants was examined, only the cognate NP366/Db ligand derived from the NP of the PR8 virus was able to trigger the activation of the TCR transfectant (Fig. 5B).
Positive_regulation (activation) of Gene_expression (transfectant) of TCR
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.14 Pain Relevance 0
Determination of IL-2 production by the TCR transfectants
Positive_regulation (by) of Gene_expression (transfectants) of TCR
16) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.17 Pain Relevance 0.04
8.2 TCR transgenic mice stimulated with MBP Ac 1-11 peptide in the presence of testosterone resulted in increased production of IL-10 and IL-5 and decreased production of IFN-?
Positive_regulation (with) of Gene_expression (transgenic mice) of TCR associated with targeted disruption
17) Confidence 0.07 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.71 Pain Relevance 0.31
Two distinct patterns of TCR-V?
Positive_regulation (patterns) of Gene_expression (patterns) of TCR
18) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.20 Pain Relevance 0
In addition, activation via CD28 is very important for re-expression of the TCR, for the recruitment and stabilization of T cell lipid rafts to the “immunological synapse” and for the stimulation of the phosphoinositide kinase-3 (PI3K) signaling pathway (Tavano et al 2004).
Positive_regulation (important) of Gene_expression (expression) of TCR in T cell
19) Confidence 0.06 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.39 Pain Relevance 0.03
Therefore, the present study showed significantly increased expression of TCR-?
Positive_regulation (increased) of Gene_expression (expression) of TCR
20) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.96 Pain Relevance 1.10

General Comments

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