INT151444

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprm1, Pag1) signal transduction (Oprm1) intracellular (Pag1)
signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 1
autonomic 1
Oprm1 (Mus musculus)
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 20 100.00 Very High Very High Very High
mu opioid receptor 8 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Central nervous system 2 88.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothalamus, NTS, and PAG are closely involved in modulation of vocalization, autonomic and neuroendocrine functions, pain, and defensive behavior through endogenous opioid peptides that bind to the MOR in these regions.
MOR Binding (bind) of PAG in autonomic associated with pain, mu opioid receptor, endogenous opioid and central grey
1) Confidence 0.00 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18421704 Disease Relevance 0.72 Pain Relevance 0.69
They also suggest that EMs released from hypothalamus-PAG projecting neurons might mediate or modulate various functions of the PAG through binding to the MOR.
MOR Spec (might) Binding (binding) of PAG in neurons associated with mu opioid receptor and central grey
2) Confidence 0.00 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18421704 Disease Relevance 0.78 Pain Relevance 0.55

General Comments

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