INT151449

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 12.05
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
epidermis 8
stem cell 4
hematopoietic stem cells 2
neurons 2
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 96 98.68 Very High Very High Very High
imagery 59 98.44 Very High Very High Very High
qutenza 2 98.24 Very High Very High Very High
Calcitonin gene-related peptide 4 96.48 Very High Very High Very High
Neurotransmitter 26 95.36 Very High Very High Very High
c fibre 1 92.80 High High
unmyelinated 1 92.44 High High
Antiemetics 1 90.32 High High
Dorsal horn 1 88.12 High High
Pain 11 82.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 314 99.60 Very High Very High Very High
Diarrhoea 9 97.72 Very High Very High Very High
Nervous System Injury 3 97.28 Very High Very High Very High
Metastasis 68 96.24 Very High Very High Very High
Skin Cancer 201 95.80 Very High Very High Very High
Gastrointestinal Stromal Tumor 162 94.96 High High
Stress 45 94.12 High High
Vomiting 14 90.32 High High
Confusion 2 89.00 High High
Pressure And Volume Under Development 29 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell-size profiles showed that c-kit receptor expression was significantly up-regulated and down-regulated in medium-sized DRG neurons after neonatal capsaicin treatment and nerve injury, respectively.
Negative_regulation (down-regulated) of Gene_expression (expression) of c-kit in neurons associated with nervous system injury and qutenza
1) Confidence 0.45 Published 2008 Journal Neuroscience Section Abstract Doc Link 18423881 Disease Relevance 0.31 Pain Relevance 1.17
The impaired viability of Kit mutants is associated with an altered hepatic lipid metabolism
Negative_regulation (viability) of Gene_expression (mutants) of Kit
2) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.22 Pain Relevance 0
The exceptions were very clearly described in the paper of Christopher et al.; including fixation artifact, technical error of immunostaining, sampling error, cessation of Kit expression perhaps following STI-571 therapy and very rare cases (2%) with real lack of Kit mutation and/or Kit expression (15).
Negative_regulation (cessation) of Gene_expression (expression) of Kit
3) Confidence 0.42 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0
Several known antioxidant genes, including Glo1, Prdx5, Sepp1, and Stk25, were all repressed in basal epidermis of Kit+/Kit+ animals but not KitW-v/KitW-v animals.
Negative_regulation (repressed) of Gene_expression (animals) of KitW-v in epidermis
4) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.84 Pain Relevance 0
Several known antioxidant genes, including Glo1, Prdx5, Sepp1, and Stk25, were all repressed in basal epidermis of Kit+/Kit+ animals but not KitW-v/KitW-v animals.
Negative_regulation (repressed) of Gene_expression (animals) of KitW-v in epidermis
5) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.85 Pain Relevance 0
Moreover, tumor shrinkage could be observed even in cases with less favorable KIT/PDGFR?
Negative_regulation (less) of Gene_expression (favorable) of KIT associated with cancer
6) Confidence 0.36 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.00 Pain Relevance 0
Moreover, tumor shrinkage could be observed even in cases with less favorable KIT/PDGFR?
Negative_regulation (even) of Gene_expression (observed) of KIT associated with cancer
7) Confidence 0.36 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.06 Pain Relevance 0
Several known antioxidant genes, including Glo1, Prdx5, Sepp1, and Stk25, were all repressed in basal epidermis of Kit+/Kit+ animals but not KitW-v/KitW-v animals.
Negative_regulation (repressed) of Gene_expression (animals) of Kit in epidermis
8) Confidence 0.35 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.84 Pain Relevance 0
Several known antioxidant genes, including Glo1, Prdx5, Sepp1, and Stk25, were all repressed in basal epidermis of Kit+/Kit+ animals but not KitW-v/KitW-v animals.
Negative_regulation (repressed) of Gene_expression (animals) of Kit in epidermis
9) Confidence 0.35 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.84 Pain Relevance 0
No expression of MHC class II, CD80, CD86, CD133, Sca1, and c-kit (CD117) was detected, indicating that BM-MC still have an immature phenotype, but without expressing stem cell surface markers (Figure 2A).
Negative_regulation (detected) of Gene_expression (expression) of CD117 in stem cell
10) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.39 Pain Relevance 0.09
No expression of MHC class II, CD80, CD86, CD133, Sca1, and c-kit (CD117) was detected, indicating that BM-MC still have an immature phenotype, but without expressing stem cell surface markers (Figure 2A).
Negative_regulation (detected) of Gene_expression (expression) of c-kit in stem cell
11) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.39 Pain Relevance 0.09
The onset of differentiation after 5 days of culture and the gradual loss of Sca-1, c-Kit and Musashi-1 expression after 3 days of culture indicated that for subsequent functional experiments employing transplantation, cells that had been cultured for 3 days were most suitable.


Negative_regulation (loss) of Gene_expression (expression) of c-Kit
12) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0 Pain Relevance 0
Also, flow cytometry analysis revealed that the bone marrow cell compartments enriched in long-term repopulating hematopoietic stem cells, defined here as KLS (c-Kit+ Sca1+ lineages?)
Negative_regulation (defined) of Gene_expression (lineages) of c-Kit in hematopoietic stem cells
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759285 Disease Relevance 0 Pain Relevance 0
Approximately 35% of GISTs lacking KIT mutations have intragenic activation mutations in PDGFR-?
Negative_regulation (lacking) of Neg (lacking) Gene_expression (mutations) of KIT
14) Confidence 0.12 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.17 Pain Relevance 0
Imaging of nitrergic neurotransmission may help distinguish between disorders due to impaired NO production such as nNOS deficiency and those due to impaired NO action such as seen in deficiencies of NO sensitive guanylyl cyclase [4], cGMP kinase1 [5], Collagen XIXa1 [6] or c-kit [24].
Negative_regulation (impaired) of Neg (NO) Gene_expression (production) of c-kit associated with imagery
15) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.42 Pain Relevance 0.40
Imaging of nitrergic neurotransmission may help distinguish between disorders due to impaired NO production such as nNOS deficiency and those due to impaired NO action such as seen in deficiencies of NO sensitive guanylyl cyclase [4], cGMP kinase1 [5], Collagen XIXa1 [6] or c-kit [24].
Negative_regulation (impaired) of Gene_expression (deficiency) of c-kit associated with imagery
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.42 Pain Relevance 0.40
Alternatively, the inhibition of c-Kit, which is highly expressed in the interstitial pace maker cells of Cajal, has been discussed (Deininger et al 2003; Popescu et al 2006).
Negative_regulation (inhibition) of Gene_expression (expressed) of c-Kit
17) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 1.46 Pain Relevance 0.05
Tumor cells from a subset of cases were also associated with strong expression of vimentin (22/22, 100%) and an absence of CD117 expression (0%, 5/5).
Negative_regulation (absence) of Gene_expression (expression) of CD117 associated with cancer
18) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2984427 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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