INT151450

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 13.11
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
interstitial cells 6
smooth muscle 2
canals 2
neurons 2
lung 2
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 98.68 Very High Very High Very High
qutenza 2 97.48 Very High Very High Very High
Calcitonin gene-related peptide 4 96.48 Very High Very High Very High
c fibre 1 92.80 High High
unmyelinated 1 92.44 High High
Dorsal horn 1 88.12 High High
Pain 14 80.56 Quite High
cva 16 80.16 Quite High
cytokine 109 77.76 Quite High
withdrawal 2 76.04 Quite High
Disease Link Frequency Relevance Heat
Cancer 710 99.58 Very High Very High Very High
Hematological Disease 7 98.96 Very High Very High Very High
Seminoma 6 97.76 Very High Very High Very High
Adenoid Cystic Carcinoma 3 97.32 Very High Very High Very High
Gastrointestinal Stromal Tumor 398 97.12 Very High Very High Very High
Nervous System Injury 1 96.52 Very High Very High Very High
Melanoma 3 96.24 Very High Very High Very High
Lung Cancer 6 95.24 Very High Very High Very High
Confusion 9 88.48 High High
Leiomyosarcoma 31 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Kit in interstitial cells
1) Confidence 0.69 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03
KIT overexpression is common in a variety of tumor types including GISTs, seminomas, adenoid cystic carcinomas, malignant melanomas, and lung carcinomas (non-small cell and small cell types) (Takahashi et al 1995; Went et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of KIT in lung associated with seminoma, lung cancer, melanoma, cancer and adenoid cystic carcinoma
2) Confidence 0.62 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.98 Pain Relevance 0
point mutation and protein activation, superimposed on the original mutation in that gene. 2) KIT genomic amplification with overexpression of the KIT oncoprotein, without a new point mutation. 3) Target modulation – activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression. 4) Functional resistance – KIT or PDGFR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of KIT oncoprotein
3) Confidence 0.62 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.19 Pain Relevance 0
They are defined as primary mesenchymal tumors, typically staining positive for the expression of c-KIT protein [1].
Positive_regulation (positive) of Gene_expression (expression) of c-KIT associated with cancer
4) Confidence 0.60 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1343558 Disease Relevance 0.82 Pain Relevance 0
Cell-size profiles showed that c-kit receptor expression was significantly up-regulated and down-regulated in medium-sized DRG neurons after neonatal capsaicin treatment and nerve injury, respectively.
Positive_regulation (up-regulated) of Gene_expression (expression) of c-kit in neurons associated with nervous system injury and qutenza
5) Confidence 0.54 Published 2008 Journal Neuroscience Section Abstract Doc Link 18423881 Disease Relevance 0.31 Pain Relevance 1.17
After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Kit in interstitial cells
6) Confidence 0.50 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.33 Pain Relevance 0.03
After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD117 in interstitial cells
7) Confidence 0.50 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03
Peritoneal cells were also stained with CD117 (c-kit) and Fc?
Positive_regulation (also) of Gene_expression (stained) of c-kit
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0
Peritoneal cells were also stained with CD117 (c-kit) and Fc?
Positive_regulation (with) of Gene_expression (stained) of c-kit
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0
The exceptions were very clearly described in the paper of Christopher et al.; including fixation artifact, technical error of immunostaining, sampling error, cessation of Kit expression perhaps following STI-571 therapy and very rare cases (2%) with real lack of Kit mutation and/or Kit expression (15).
Positive_regulation (following) of Gene_expression (expression) of Kit
10) Confidence 0.46 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0
Exons 8 through 13 c-kit coding regions were sequenced for WT816 patients
Positive_regulation (sequenced) of Gene_expression (regions) of kit
11) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0 Pain Relevance 0
Thereafter, Kit expression was confined to a few cells located in the hepatic parenchyma and was also found in the epithelial cells of the biliary canals at later stages and in adults.
Positive_regulation (confined) of Gene_expression (expression) of Kit in canals
12) Confidence 0.41 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.29 Pain Relevance 0
point mutation and protein activation, superimposed on the original mutation in that gene. 2) KIT genomic amplification with overexpression of the KIT oncoprotein, without a new point mutation. 3) Target modulation – activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression. 4) Functional resistance – KIT or PDGFR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of KIT
13) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.24 Pain Relevance 0
Peritoneal cells were also stained with CD117 (c-kit) and Fc?
Positive_regulation (also) of Gene_expression (stained) of CD117
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0
Peritoneal cells were also stained with CD117 (c-kit) and Fc?
Positive_regulation (with) of Gene_expression (stained) of CD117
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0
Peritoneal lavage was performed and the recovered cells contained a distinct population of CD117+/Fc?
Positive_regulation (population) of Gene_expression (/) of CD117
16) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.07
The number of c-Kit+ stem cells, and gene expression of SDF-1, VEGF and bFGF were obviously increased, which was associated with reduced infarct size, thicker left ventricle wall, greater vascular density and cardiocytes density in infarcted hearts of AdV-SDF-1 group.
Positive_regulation (increased) of Gene_expression (expression) of c-Kit in hearts
17) Confidence 0.20 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.46 Pain Relevance 0
Gain-of-function mutations in the c-kit proto-oncogene and overexpression of the kit protein can occur [4,5], and result in a constitutive stimulus to tumor cell growth.
Positive_regulation (overexpression) of Gene_expression (overexpression) of kit associated with cancer
18) Confidence 0.18 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1633731 Disease Relevance 0.93 Pain Relevance 0
Gain-of-function mutations in the c-kit proto-oncogene and overexpression of the kit protein can occur [4,5], and result in a constitutive stimulus to tumor cell growth.
Positive_regulation (overexpression) of Gene_expression (overexpression) of kit associated with cancer
19) Confidence 0.17 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1633731 Disease Relevance 0.93 Pain Relevance 0
Likewise, overexpression of PDGF and c-kit was also observed in Leydig tumors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-kit associated with cancer
20) Confidence 0.16 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.90 Pain Relevance 0

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