INT15146

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Context Info
Confidence 0.53
First Reported 1991
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
Plasma 2
spinal cord 2
spinal cord neurons 2
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 14 100.00 Very High Very High Very High
Calcitonin gene-related peptide 7 100.00 Very High Very High Very High
pruritus 59 99.48 Very High Very High Very High
Spinal cord 9 99.44 Very High Very High Very High
tetrodotoxin 12 97.36 Very High Very High Very High
Neurotransmitter 2 94.80 High High
Action potential 2 89.52 High High
Neuropeptide 14 74.64 Quite High
Somatostatin 2 60.28 Quite High
unmyelinated 1 47.08 Quite Low
Disease Link Frequency Relevance Heat
Pruritus 78 99.48 Very High Very High Very High
Psoriasis 60 70.64 Quite High
Eczema 10 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Nicotine Addiction 2 5.00 Very Low Very Low Very Low
Uremia 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Skin Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous electrical activity regulates vasoactive intestinal peptide expression in dissociated spinal cord cell cultures.
Regulation (regulates) of Gene_expression (expression) of vasoactive intestinal peptide in spinal cord associated with spinal cord
1) Confidence 0.53 Published 1991 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1715967 Disease Relevance 0 Pain Relevance 0.61
In summary, the regulation of VIP gene expression in embryonic spinal cord neurons shows a temporal sensitivity to TTX-induced electrical blockade and may be mediated by multiple neurotransmitter inputs which converge on cAMP- and calcium-related processes in an activity-dependent manner.
Regulation (regulation) of Gene_expression (expression) of VIP gene in spinal cord neurons associated with tetrodotoxin, neurotransmitter and spinal cord
2) Confidence 0.27 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1715967 Disease Relevance 0 Pain Relevance 0.71
Plasma levels of SP, CGRP, and VIP did not differ significantly
Neg (not) Regulation (differ) of Gene_expression (levels) of VIP in Plasma associated with calcitonin gene-related peptide and substance p
3) Confidence 0.17 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.89 Pain Relevance 0.92

General Comments

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