INT151461

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
paw 2
Olr1745 (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5 100.00 Very High Very High Very High
cytokine 3 100.00 Very High Very High Very High
Thermal hyperalgesia 1 92.52 High High
Potency 1 77.76 Quite High
Analgesic 2 75.00 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Hyperalgesia 1 92.52 High High
Pressure And Volume Under Development 1 90.76 High High
Arthritis 3 77.04 Quite High
Nociception 1 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistic studies showed that JCICM-6 effectively decreased the production of the pro-inflammatory cytokines of IL-6 and IL-1beta and expression of COX-2 and iNOS proteins, and simultaneously elevated the level of anti-inflammatory cytokine IL-4 in the carrageenan-injected rat paw tissues and exudates.
JCICM-6 Negative_regulation (decreased) of Gene_expression (production) of IL-6 in paw associated with inflammation and cytokine
1) Confidence 0.03 Published 2008 Journal Phytomedicine Section Abstract Doc Link 18424100 Disease Relevance 0.81 Pain Relevance 0.57

General Comments

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