INT151466

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
cleavage 1
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 87.88 High High
cINOD 5 71.48 Quite High
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
palliative 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 99 99.90 Very High Very High Very High
Hepatocellular Cancer 11 99.10 Very High Very High Very High
Toxicity 12 91.28 High High
Neuroblastoma 7 79.84 Quite High
Neurodegenerative Disease 3 79.32 Quite High
Liver Cancer 3 75.00 Quite High
Cancer 16 64.32 Quite High
INFLAMMATION 1 53.20 Quite High
Alzheimer's Dementia 6 50.00 Quite Low
Death 11 32.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once released into the cytosol, cyto c binds with procaspase-9 in the presence of ATP and Apaf-1 to form the apoptosome.
caspase-9 Binding (binds) of
1) Confidence 0.36 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.98 Pain Relevance 0
In HuH-6 hepatoma cells the combination-induced apoptosis was associated with caspase-9 and -3 activation, PARP cleavage, release of cytochrome c from the mitochondria into the cytosol and down-regulation of survivin and beta-catenin levels.
caspase-9 Binding (associated) of in cleavage associated with hepatocellular cancer and apoptosis
2) Confidence 0.18 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.79 Pain Relevance 0.50
They, damaging the mitochondria, cause a release of the cytochrome C that, in turn, induces activation of the intrinsic apoptotic pathway by the intervention of the caspase 9.
caspase 9 Binding (intervention) of associated with apoptosis
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.68 Pain Relevance 0

General Comments

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