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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.62
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
cleavage 2
hepatocytes 1
B-cell 1
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.82 Very High Very High Very High
antagonist 3 96.00 Very High Very High Very High
ischemia 18 93.76 High High
COX-2 inhibitor 7 87.24 High High
cINOD 28 85.48 High High
Eae 6 84.00 Quite High
Inflammation 50 81.20 Quite High
Pain 4 74.12 Quite High
Kinase C 5 64.04 Quite High
aspirin 9 56.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 315 99.58 Very High Very High Very High
Hepatocellular Cancer 34 98.78 Very High Very High Very High
Hypothermia 138 98.64 Very High Very High Very High
Lymphatic System Cancer 2 98.20 Very High Very High Very High
Disease 130 96.96 Very High Very High Very High
Cv General 4 Under Development 1 94.64 High High
Cancer 79 92.24 High High
Death 116 92.12 High High
Colon Cancer 10 89.76 High High
INFLAMMATION 59 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moderate hypothermia has been shown to suppress Fas-mediated apoptosis in stored cultured hepatocytes, along with suppression of cytochrome-c release from mitochondria and downstream activation of caspase-7 and caspase-9 [103].
Localization (release) of caspase-9 in hepatocytes associated with hypothermia and apoptosis
1) Confidence 0.73 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.09 Pain Relevance 0.22
Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].
Localization (release) of caspase-9 in B-cell associated with lymphatic system cancer, antagonist and apoptosis
2) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.14 Pain Relevance 0.05
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Localization (translocation) of caspase-9 in cleavage associated with qutenza
3) Confidence 0.38 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.09 Pain Relevance 0.76
Caspase-9 activation was quite similar in both PBS and HMW-HA treatments, except at the dose 75 mJ/cm2 of UVB, which indicated a significant caspase-9 decrease (?
Localization (decrease) of caspase-9
4) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.19 Pain Relevance 0
In HuH-6 hepatoma cells the combination-induced apoptosis was associated with caspase-9 and -3 activation, PARP cleavage, release of cytochrome c from the mitochondria into the cytosol and down-regulation of survivin and beta-catenin levels.
Localization (release) of caspase-9 in cleavage associated with hepatocellular cancer and apoptosis
5) Confidence 0.36 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.79 Pain Relevance 0.50
In the present work, we showed that apoptosis occurs mainly via the mitochondrial pathway, with early mitochondrial membrane depolarization followed by cytochrome c release into the cytoplasm and caspase-9 and -3 activation.
Localization (release) of caspase-9 associated with apoptosis
6) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 1.09 Pain Relevance 0.44
To support this notion, our results clearly demonstrated that the active form of caspase-9 was increased and the precursor of caspase-3 was cleaved significantly after Pa-PDT treatment (Figure 5A).
Localization (form) of caspase-9
7) Confidence 0.12 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.74 Pain Relevance 0
This module is characterized by one initiator caspase (caspase-8 or caspase-9) activated by the trigger events and several executioner caspases (caspases-3, -6, -7).
Localization (caspase-8) of caspase-9
8) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.50 Pain Relevance 0.07
The antibodies against caspase3, caspase8, caspase9, DR5, Bcl-2, Bax and ?
Localization (caspase9) of caspase9
9) Confidence 0.00 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0 Pain Relevance 0

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