INT151468

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
macrophage 1
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 100.00 Very High Very High Very High
Inflammation 30 100.00 Very High Very High Very High
cINOD 5 99.04 Very High Very High Very High
COX-2 inhibitor 5 96.92 Very High Very High Very High
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Hepatocellular Cancer 6 95.72 Very High Very High Very High
Cancer 4 91.88 High High
Liver Cancer 1 75.00 Quite High
Apoptosis 3 51.60 Quite High
Sprains And Strains 1 11.84 Low Low
Hypersensitivity Pneumonitis 1 6.72 Low Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p38 MAPK pathway has been shown to affect the mRNA stability of proinflammatory genes, mainly that of mRNA for cytokines such as IL-2, IL-3, IL-6, IL-8, TNF, and GM-CSF [90-92] but also that of mRNA for cyclo-oxygenase 2 (COX-2) [93], vascular endothelial growth factor (VEGF) [94], macrophage inflammatory protein 2 (MIP-2) [91], urokinase-type plasminogen activator (uPAR) [95], and MKK6 [96].
Regulation (affect) of MKK6 in macrophage associated with inflammation and cytokine
1) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.10 Pain Relevance 0.22
Here, we examined the role of MEK/ERK1/2 signaling in the anti-neoplastic effects of both selective COX-1 and COX-2 inhibitors in two human hepatoma cell lines.
Regulation (role) of MEK associated with hepatocellular cancer and cox-2 inhibitor
2) Confidence 0.09 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.58 Pain Relevance 0.53

General Comments

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