INT15149

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.53
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
astrocytes 4
dorsal root ganglia 3
spinal cord 1
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 52 100.00 Very High Very High Very High
Spinal cord 14 98.92 Very High Very High Very High
Central nervous system 62 88.32 High High
Action potential 2 87.44 High High
tetrodotoxin 12 74.16 Quite High
medulla 3 67.28 Quite High
ischemia 2 54.64 Quite High
Inflammation 29 50.68 Quite High
Multiple sclerosis 52 37.00 Quite Low
substance P 4 28.72 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 39 99.12 Very High Very High Very High
Dementia 27 97.80 Very High Very High Very High
Neurodegenerative Disease 17 97.72 Very High Very High Very High
Cognitive Disorder 3 91.20 High High
Vascular Dementia 3 83.12 Quite High
Syndrome 7 78.52 Quite High
Chronic Fatigue Syndrome 22 75.36 Quite High
Motor Neuron Diseases 29 70.44 Quite High
Confusion 3 63.92 Quite High
Fatigue 25 60.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VNs,

such as PACAP and VIP, exert potent effects in metabolism as they have a vital

Positive_regulation (as) of Gene_expression (VNs) of VIP associated with neuropeptide
1) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.27 Pain Relevance 0.09
Activity-dependent expression of vasoactive intestinal peptide (VIP) was investigated in spinal cord/dorsal root ganglia cultures derived from embryonic mice.
Spec (investigated) Positive_regulation (dependent) of Spec (investigated) Gene_expression (expression) of vasoactive intestinal peptide in dorsal root ganglia associated with spinal cord
2) Confidence 0.40 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1715967 Disease Relevance 0 Pain Relevance 0.45
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Positive_regulation (by) of Gene_expression (/) of VIP in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
3) Confidence 0.38 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.63 Pain Relevance 0.13
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Positive_regulation (by) of Gene_expression (astrocytes) of VIP in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
4) Confidence 0.38 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.64 Pain Relevance 0.13
Activity-dependent expression of vasoactive intestinal peptide (VIP) was investigated in spinal cord/dorsal root ganglia cultures derived from embryonic mice.
Spec (investigated) Positive_regulation (dependent) of in spinal cord Spec (investigated) Gene_expression (expression) of vasoactive intestinal peptide in dorsal root ganglia associated with spinal cord
5) Confidence 0.14 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1715967 Disease Relevance 0 Pain Relevance 0.45

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