INT151513

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.73
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
Platelet 4
blood vessels 3
endothelial cell 2
bone marrow 2
granulation 2
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 99.80 Very High Very High Very High
antagonist 3 97.94 Very High Very High Very High
Calcitonin gene-related peptide 12 97.72 Very High Very High Very High
Neuropeptide 2 91.52 High High
cytokine 27 91.20 High High
dorsal root ganglion 45 90.56 High High
qutenza 2 88.08 High High
ischemia 55 85.56 High High
alcohol 2 84.88 Quite High
Sciatic nerve 15 82.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 34 100.00 Very High Very High Very High
INFLAMMATION 26 99.80 Very High Very High Very High
Bites And Stings 5 99.72 Very High Very High Very High
Wound Healing 10 99.70 Very High Very High Very High
Injury 31 98.88 Very High Very High Very High
Ganglion Cysts 46 98.44 Very High Very High Very High
Cancer 139 97.40 Very High Very High Very High
Necrosis 2 91.52 High High
Myocardial Infarction 70 88.88 High High
Stress 52 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They were next incubated with diluted mouse anti-PECAM-1 antibody (diluted 1 : 1,000, sc-1506, Santa Cruz Biotechnology, Santa Cruz, CA) overnight at 4?
Negative_regulation (diluted) of Gene_expression (antibody) of anti-PECAM-1
1) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.37 Pain Relevance 0.07
The number of CD31+ blood vessels per outlined area from 4 sections per ganglion spaced 100 ?
Negative_regulation (number) of in blood vessels Gene_expression (blood vessels) of CD31 in ganglion associated with ganglion cysts
2) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2289805 Disease Relevance 0.19 Pain Relevance 0.22
We then checked the expression of CD31 or PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) in both control tumors of hUCBSC-treated mice brain sections.
Negative_regulation (checked) of Gene_expression (expression) of PECAM-1 in Platelet associated with cancer and adhesions
3) Confidence 0.29 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.88 Pain Relevance 0
We then checked the expression of CD31 or PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) in both control tumors of hUCBSC-treated mice brain sections.
Negative_regulation (checked) of Gene_expression (expression) of CD31 in Platelet associated with cancer and adhesions
4) Confidence 0.29 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.88 Pain Relevance 0
A CGRP antagonist, CGRP8-37 when infused with mini-osmotic pumps subcutaneously blocked the wound healing processes and reduced the expressions of CD31 and VEGF expression in the wound granulation tissues.
Negative_regulation (reduced) of Gene_expression (expressions) of CD31 in granulation associated with antagonist, injury, wound healing and calcitonin gene-related peptide
5) Confidence 0.28 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18430544 Disease Relevance 0.88 Pain Relevance 0.69
LacZ+ cells displayed expression of both Sca-1 and CD31 on their cell surface (Fig. 4a).
Negative_regulation (displayed) of Gene_expression (expression) of CD31
6) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.49 Pain Relevance 0
Scoring of PECAM-1-positive blood vessels
Negative_regulation (Scoring) of Gene_expression (blood vessels) of PECAM-1-positive in blood vessels
7) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.10 Pain Relevance 0.04
Expression of the endothelial cell adhesion molecule ICAM-1 is significantly down-regulated by D. andersoni salivary gland extract, likely reducing the inflammatory response to tick bite [14].
Negative_regulation (reducing) of Gene_expression (Expression) of endothelial cell adhesion molecule ICAM-1 in endothelial cell associated with inflammatory response, bites and stings and adhesions
8) Confidence 0.09 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.63 Pain Relevance 0.17
Subsequent to the initial description, the same group reported after in vitro expansion the SVF derived cells had surface marker expression similar to bone marrow derived MSC, comprising of positive for CD29, CD44, CD71, CD90, CD105/SH2, and SH3 and lacking CD31, CD34, and CD45 expression [24].
Negative_regulation (lacking) of Gene_expression (expression) of CD31 in bone marrow
9) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.31 Pain Relevance 0.03

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