INT151525

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 8.50
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Olfr148) plasma membrane (Olfr148) signal transducer activity (Olfr148)
Anatomy Link Frequency
liver 4
endothelial cells 1
retina 1
epithelial cells 1
Olfr148 (Mus musculus)
Pain Link Frequency Relevance Heat
Etanercept 78 99.40 Very High Very High Very High
fibrosis 17 88.12 High High
Potency 158 78.56 Quite High
Paracetamol 10 75.00 Quite High
Inflammation 24 37.04 Quite Low
anesthesia 6 23.52 Low Low
rheumatoid arthritis 6 9.64 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 259 100.00 Very High Very High Very High
Diabetes Mellitus 213 99.08 Very High Very High Very High
Liver Disease 31 97.56 Very High Very High Very High
Ganglion Cysts 15 97.48 Very High Very High Very High
Hepatotoxicity 121 97.24 Very High Very High Very High
Death 96 96.84 Very High Very High Very High
Acute Liver Failure 21 95.76 Very High Very High Very High
Injury 47 91.28 High High
Weight Loss 15 90.48 High High
Toxicity 84 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate the role of M30 and M65 immunoexpression as markers for functioning liver cell mass, capacity for recovery and therefore as predictive markers in acute liver failure.
Gene_expression (immunoexpression) of M30 in liver associated with acute liver failure
1) Confidence 0.67 Published 2008 Journal Liver Int. Section Abstract Doc Link 18433398 Disease Relevance 1.53 Pain Relevance 0.19
However, weak staining of activated caspase 3, Bax and the M30 neoantigen were observed by immunohistochemistry (Supplementary Table S3).
Gene_expression (staining) of M30
2) Confidence 0.19 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.69 Pain Relevance 0.10
Histology data clearly demonstrated both LNA oligonucleotide-indiced liver necrosis and activation of apoptosis pathways, as evidenced by H&E staining, as well as cleaved caspase 3, increased Bax expression and increased expression of the M30 neo-epitope.
Gene_expression (expression) of M30 in liver associated with hepatotoxicity and apoptosis
3) Confidence 0.17 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 1.15 Pain Relevance 0
M30 immunoreactive cells appear at an early stage of apoptosis in epithelial cells, and are not detectable in vital or necrotic epithelial cells (40).
Neg (not) Gene_expression (detectable) of M30 in epithelial cells associated with apoptosis
4) Confidence 0.15 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.86 Pain Relevance 0
The cleavage of human K18 at Asp396 can be monitored using the M30 antibody (Leers et al. 1999) and M30-Ab ELISA has become a useful serologic test for determining liver disease severity.
Gene_expression (using) of M30 in liver associated with liver disease
5) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.02 Pain Relevance 0
The cleavage of human K18 at Asp396 can be monitored using the M30 antibody (Leers et al. 1999) and M30-Ab ELISA has become a useful serologic test for determining liver disease severity.
Gene_expression (using) of M30 in liver associated with liver disease
6) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.01 Pain Relevance 0
Treatment with etanercept was able to reduce TUNEL and M30 staining throughout the retina in diabetic animals (Figure 4).
Gene_expression (staining) of M30 in retina associated with diabetes mellitus and etanercept
7) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 0.93 Pain Relevance 0.19
The percentage of M30-positive endothelial cells was reduced by 41% (n=12; p<0.0001) after inhibition of TNF-?
Gene_expression (percentage) of M30 in endothelial cells
8) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 0.95 Pain Relevance 0.19
Terminal transferase dUTP nick end labeling and M30 staining
Gene_expression (staining) of M30
9) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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