INT151540

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 6.08
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Anatomy Link Frequency
neurons 3
neuronal 1
brains 1
Fmr1 (Mus musculus)
Fmr1 - I304N (2)
Pain Link Frequency Relevance Heat
agonist 62 99.24 Very High Very High Very High
Glutamate receptor 36 99.00 Very High Very High Very High
Anterior cingulate cortex 15 98.08 Very High Very High Very High
Lasting pain 4 97.48 Very High Very High Very High
addiction 3 96.64 Very High Very High Very High
peripheral neuropathy 2 95.88 Very High Very High Very High
depression 23 91.44 High High
isoflurane 7 39.76 Quite Low
imagery 7 33.60 Quite Low
Immobilon 7 10.56 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 228 100.00 Very High Very High Very High
Neurological Disease 12 99.88 Very High Very High Very High
Syndrome 140 98.94 Very High Very High Very High
Ataxia 29 98.76 Very High Very High Very High
Tremor 55 98.62 Very High Very High Very High
Cognitive Disorder 54 98.52 Very High Very High Very High
Fragile X Syndrome 147 97.68 Very High Very High Very High
Pain 23 97.48 Very High Very High Very High
Parkinson's Disease 12 97.36 Very High Very High Very High
Drug Dependence 3 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation.
Regulation (regulation) of FMRP
1) Confidence 0.59 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434517 Disease Relevance 0.31 Pain Relevance 0.36
We propose that this leads to a loss of proper translational control of FMRP mRNA targets, which in turn leads to the cognitive and behavioral deficits observed in the Fragile X Syndrome.
Regulation (control) of FMRP mRNA associated with cognitive disorder and fragile x syndrome
2) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.57 Pain Relevance 0
Several attempts have been made to assess the effect of the I304N mutation on FMRP RNA binding and function.
Regulation (effect) of FMRP RNA
3) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
The amount of Fmr1 mRNA in each fraction was then plotted as a percentage of total Fmr1 mRNA summed over the entire polyribosome gradient.
Regulation (amount) of Fmr1
4) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Generation of targeted Fmr1 I304N knock-in mutation
Regulation (targeted) of Fmr1 (I304N) associated with targeted disruption
5) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.61 Pain Relevance 0
Here we demonstrate that LTD induced with either chemical or synaptic stimulation is independent of protein synthesis in the Fmr1I304N mice, recapitulating the Fmr1 null phenotype (Figure 3).
Regulation (recapitulating) of Fmr1
6) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.18 Pain Relevance 0.04
Our laboratory has shown that FMRP and PSD-95 mRNAs are rapidly translated in mouse primary cortical neurons in response to the type 1 mGluR agonist DHPG [22].
Regulation (translated) of FMRP in neurons associated with agonist
7) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.41 Pain Relevance 0.08
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
Regulation (regulation) of FMRP associated with glutamate receptor
8) Confidence 0.43 Published 2008 Journal J. Neurosci. Section Title Doc Link 18434517 Disease Relevance 0.53 Pain Relevance 0.33
Nonetheless, based on our finding of decreased I304N FMRP in the mouse model and similar results from the I307N mutation in dfmr1 [77], we infer that it is most likely that the I304N patient has lower steady state levels of neuronal I304N-FMRP.


Spec (likely) Regulation (has) of I304N-FMRP (I304N) in neuronal
9) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.79 Pain Relevance 0
To examine whether the I304N mutation affected endogenous FMRP-polyribosome association in the brain, we examined the distribution of the mutant protein in the brains of Fmr1I304N mice.
Spec (whether) Regulation (affected) of FMRP in brains
10) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Most of the previous studies have been focused on downstream targets of FMRP in hippocampal neurons, and fewer studies have been reported for the second-messenger signaling pathways between group I mGluRs and FMRP.
Regulation (targets) of FMRP in neurons
11) Confidence 0.38 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434517 Disease Relevance 0.54 Pain Relevance 0.35
The rapid dissociation of FMRP from APP mRNA, in response to mGluR activation, suggests that post-translational modifications, such as phosphorylation, may regulate FMRP binding activity.
Spec (may) Regulation (regulate) of FMRP
12) Confidence 0.27 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.05 Pain Relevance 0
Thus, APP mRNA is a potential target of FMRP, presumably via the coding region putative G-quartet.


Regulation (target) of FMRP
13) Confidence 0.27 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.26 Pain Relevance 0
Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurological disorder that affects older adult carriers, predominantly males, of premutation alleles (55 to 200 CGG repeats) of the fragile X (FMR1) gene.

Regulation (affects) of FMR1 associated with tremor, neurological disease, ataxia and syndrome
14) Confidence 0.26 Published 2008 Journal Clinical Interventions in Aging Section Title Doc Link PMC2546470 Disease Relevance 1.43 Pain Relevance 0.09
Normal regulation was lost in fmr-1 KO-derived neurons, implicating FMRP in this process.
Regulation (regulation) of FMRP in neurons associated with targeted disruption
15) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.40 Pain Relevance 0.08

General Comments

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