INT151546

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0.37

nucleus (Adcy1, Atf2) lyase activity (Adcy1) intracellular (Atf2) plasma membrane (Adcy1) DNA binding (Atf2)

Adcy1 (Mus musculus) Atf2 (Mus musculus)

Pain Link Frequency Relevance Heat Anterior cingulate cortex 5 99.40 Glutamate receptor 2 75.00 Lasting pain 1 62.68 addiction 1 61.84

Disease Link Frequency Relevance Heat Cognitive Disorder 1 76.80 Pain 1 62.68 Drug Dependence 1 61.84 Mental Disorders 1 61.20 Intellectual Impairment 1 53.16 Syndrome 2 51.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation.

AC1 Positive_regulation (activation) of cAMP response element-binding protein

1) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434517 Disease Relevance 0.37 Pain Relevance 0.37

General Comments

This test has worked.