INT15155

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Context Info
Confidence 0.62
First Reported 1987
Last Reported 1994
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.67
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
atrial wall 4
plasma 2
cardiocytes 2
sympathetic nervous system 2
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 8 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Opioid 2 99.32 Very High Very High Very High
Enkephalin 7 99.08 Very High Very High Very High
Kappa opioid receptor 5 98.32 Very High Very High Very High
adenocard 1 95.80 Very High Very High Very High
Angina 3 94.96 High High
Clonidine 4 94.64 High High
opioid receptor 1 89.44 High High
Catecholamine 2 83.68 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 15 100.00 Very High Very High Very High
Heart Rate Under Development 4 100.00 Very High Very High Very High
Coronary Artery Disease 15 95.92 Very High Very High Very High
Angina 3 94.96 High High
Pressure And Volume Under Development 3 69.28 Quite High
Cv Unclassified Under Development 6 43.60 Quite Low
Depression 3 38.72 Quite Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to assess whether dipyridamole infusion (up to 0.84 mg kg-1 over 10') can affect ANF release in man.
Regulation (affect) of Localization (release) of ANF
1) Confidence 0.62 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.51 Pain Relevance 0.09
Atrial natriuretic factor (ANF) release is modulated by several haemodynamic factors, including ventricular and atrial wall stretch.
Regulation (modulated) of Localization (release) of Atrial natriuretic factor in atrial wall associated with natriuresis
2) Confidence 0.62 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.40 Pain Relevance 0.06
Since changes in right atrial pressure have been shown to influence ANF release, central venous pressure (CVP) was continuously measured 30 min before, during the 120 min duration of drug infusions, and for 30 min after the bolus injections of the drugs.
Regulation (influence) of Localization (release) of ANF
3) Confidence 0.62 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.16 Pain Relevance 0.19
Atrial natriuretic factor (ANF) release is modulated by several haemodynamic factors, including ventricular and atrial wall stretch.
Regulation (modulated) of Localization (release) of ANF in atrial wall associated with natriuresis
4) Confidence 0.45 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.40 Pain Relevance 0.06
The results do not suggest a major role for adrenoceptor-mediated ANF release in normal humans, and do not indicate that plasma ANF levels are determined by tonic inhibition or facilitation of the sympathetic nervous system.
Regulation (role) of Localization (release) of ANF in sympathetic nervous system
5) Confidence 0.45 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.13 Pain Relevance 0.20
In order to study the effect of atrial tachycardia on the release of atrial natriuretic peptide (ANP), AVP, and methionine enkephalin (M-Enk), plasma concentrations of these peptides in the right ventricle were determined in patients with various arrhythmias (N = 10) during cardiac catheterization and incremental atrial pacing.
Regulation (effect) of Localization (release) of ANP in plasma associated with natriuresis, heart rate under development and enkephalin
6) Confidence 0.38 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2958984 Disease Relevance 0.28 Pain Relevance 0.17
It has been suggested that opioids could play a significant role in controlling ANP release.
Regulation (controlling) of Localization (release) of ANP associated with opioid
7) Confidence 0.27 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.27 Pain Relevance 0.14
Influence of endogenous opioids on atrial natriuretic factor release during exercise in man.
Regulation (Influence) of Localization (release) of atrial natriuretic factor associated with natriuresis and endogenous opioid
8) Confidence 0.26 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Title Doc Link 2555188 Disease Relevance 0.33 Pain Relevance 0.24
The present study was designed to investigate the direct effect of dynorphin on atrial natriuretic polypeptide (ANP) secretion in cultured rat atrial cardiocytes via a kappa-opioid receptor activation as well as the involvement of adenosine 3',5'-cyclic monophosphate (cAMP) system in the secretion of ANP from cardiocytes.
Spec (investigate) Regulation (effect) of Localization (secretion) of natriuretic polypeptide in cardiocytes associated with natriuresis, adenocard, dynorphin and kappa opioid receptor
9) Confidence 0.00 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1716056 Disease Relevance 0.17 Pain Relevance 0.49

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