INT15156

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2004
Negated 1
Speculated 2
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 8.61
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 2
atrial wall 2
sympathetic 2
cardiocytes 2
sympathetic nervous system 2
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 15 100.00 Very High Very High Very High
depression 7 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Enkephalin 17 99.86 Very High Very High Very High
narcan 10 99.86 Very High Very High Very High
Dynorphin 24 99.84 Very High Very High Very High
opiate 10 99.64 Very High Very High Very High
Opioid 3 99.54 Very High Very High Very High
ischemia 6 99.52 Very High Very High Very High
Endogenous opioid 8 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 47 100.00 Very High Very High Very High
Depression 7 100.00 Very High Very High Very High
Coronary Artery Disease 26 99.98 Very High Very High Very High
Cv Unclassified Under Development 7 98.96 Very High Very High Very High
Diabetic Neuropathy 1 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 3 98.28 Very High Very High Very High
Stress 3 97.72 Very High Very High Very High
Pressure Volume 2 Under Development 6 97.30 Very High Very High Very High
Hyponatremia 5 95.60 Very High Very High Very High
Heart Rate Under Development 16 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that dipyridamole infusion does not increase ANF release in man in the absence of ischaemia.
Neg (not) Positive_regulation (increase) of Localization (release) of ANF associated with cv unclassified under development
1) Confidence 0.70 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.71 Pain Relevance 0.11
Dipyridamole-induced myocardial ischaemia increases ANF release in man.
Positive_regulation (increases) of Localization (release) of ANF associated with coronary artery disease
2) Confidence 0.70 Published 1991 Journal Eur. Heart J. Section Title Doc Link 1830552 Disease Relevance 0.63 Pain Relevance 0.10
To evaluate to what extent opioid secretion in exercise induces the release of atrial natriuretic factor (ANF), six healthy male volunteers who were trained subjects, were submitted to two maximal exercise tests with and without (control) opioid receptor blockade by Naltrexone.
Positive_regulation (induces) of Localization (release) of ANF associated with natriuresis, opioid receptor and opioid
3) Confidence 0.67 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.25 Pain Relevance 0.22
To evaluate to what extent the endogenous opioid secretion during exercise induces the ANP release, six healthy volunteers male trained subjects were submitted to two maximal exercise tests with and without (placebo) opiate receptors blockade by naltrexone (50 mg per os).
Positive_regulation (induces) of Localization (release) of ANP associated with endogenous opioid and opiate
4) Confidence 0.61 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.24 Pain Relevance 0.46
To assess the potential role of adrenoceptor-stimulated atrial natriuretic factor (ANF) release in healthy humans, 18 volunteers, divided into groups of six, underwent experiments with infusion of incremental doses of salbutamol with and without beta-blockade with propranolol, propranolol alone, and bolus injections of clonidine before and after alpha-blockade with phentolamine, and phentolamine alone.
Positive_regulation (adrenoceptor-stimulated) of Localization (release) of ANF associated with natriuresis and clonidine
5) Confidence 0.50 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.17 Pain Relevance 0.09
The results do not suggest a major role for adrenoceptor-mediated ANF release in normal humans, and do not indicate that plasma ANF levels are determined by tonic inhibition or facilitation of the sympathetic nervous system.
Positive_regulation (adrenoceptor-mediated) of Localization (release) of ANF in sympathetic nervous system
6) Confidence 0.50 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.13 Pain Relevance 0.20
To assess the potential role of adrenoceptor-stimulated atrial natriuretic factor (ANF) release in healthy humans, 18 volunteers, divided into groups of six, underwent experiments with infusion of incremental doses of salbutamol with and without beta-blockade with propranolol, propranolol alone, and bolus injections of clonidine before and after alpha-blockade with phentolamine, and phentolamine alone.
Positive_regulation (adrenoceptor-stimulated) of Localization (release) of atrial natriuretic factor associated with natriuresis and clonidine
7) Confidence 0.50 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.17 Pain Relevance 0.09
Animal data suggest that opiates, halothane anaesthesia and activation of the sympathetic system stimulates release of atrial natriuretic peptide (ANP).
Positive_regulation (stimulates) of Localization (release) of ANP in sympathetic associated with natriuresis, halothane and opiate
8) Confidence 0.49 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2964965 Disease Relevance 0.17 Pain Relevance 0.33
These data demonstrate that: (1) ANF secretion during exercise is influenced by the level of beta-endorphin in the plasma; (2) the possible inhibitory role of ANF on aldosterone secretion during exercise is probably over-ruled by the increase in plasma ACTH and PRA.
Spec (possible) Positive_regulation (influenced) of Localization (secretion) of ANF in plasma
9) Confidence 0.48 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.29 Pain Relevance 0.16
To evaluate to what extent opioid secretion in exercise induces the release of atrial natriuretic factor (ANF), six healthy male volunteers who were trained subjects, were submitted to two maximal exercise tests with and without (control) opioid receptor blockade by Naltrexone.
Positive_regulation (induces) of Localization (release) of atrial natriuretic factor associated with natriuresis, opioid receptor and opioid
10) Confidence 0.48 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.25 Pain Relevance 0.22
In conclusion, ANP attenuates ischemic ST-segment depression and lactate release during pacing-induced myocardial ischemia in patients with CAD.
Positive_regulation (pacing-induced) of Localization (release) of ANP associated with coronary artery disease, depression and ischemia
11) Confidence 0.48 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9972741 Disease Relevance 1.39 Pain Relevance 0.60
The induction of myocardial ischaemia acutely increases ANF release, probably through a rise in ventricular and atrial wall stress.
Spec (probably) Positive_regulation (increases) of Localization (release) of ANF in atrial wall associated with stress and coronary artery disease
12) Confidence 0.47 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.73 Pain Relevance 0.10
On the other hand, it was evidenced that morphine and opiate peptides greatly stimulate ANP release.
Positive_regulation (stimulate) of Localization (release) of ANP associated with opiate and morphine
13) Confidence 0.41 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.23 Pain Relevance 0.45
This effect was attributed to the hemodynamic changes of exercise which could increase atrial volume and result in ANP secretion.
Positive_regulation (result) of Localization (secretion) of ANP
14) Confidence 0.41 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.23 Pain Relevance 0.43
HOI caused significant decrements of MAP, PRA, aldosterone, and catecholamines, and increased ANP, GFR, from 94 +/- 5 to 102 +/- 5 ml/min (P < 0.01), ERPF, from 529 +/- 30 to 616 +/- 35 ml/min (P < 0.01), and sodium excretion.
Positive_regulation (increased) of Localization (decrements) of ANP associated with catecholamine
15) Confidence 0.40 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.36 Pain Relevance 0.41
These results indicate that atrial pacing stimulates ANP release with a rise in right atrial pressure, but does not influence M-Enk and AVP releases.
Positive_regulation (stimulates) of Localization (release) of ANP
16) Confidence 0.40 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2958984 Disease Relevance 0.19 Pain Relevance 0.13
These results suggest that exaggerated ADH release (SIADH) was brought about by the baroreceptor reflex stimulated by the postural hypotension, and also by the impaired osmoregulation associated with diabetic neuropathy, and that droxidopa improved cardiovascular function and increased ANP release with resultant urinary dilution and natriuresis in spite of slightly increased ADH release.
Positive_regulation (increased) of Localization (release) of ANP associated with natriuresis, hyponatremia, pressure volume 2 under development and diabetic neuropathy
17) Confidence 0.32 Published 1991 Journal Endocrinol. Jpn. Section Abstract Doc Link 1794339 Disease Relevance 1.11 Pain Relevance 0.05
Blockage of K+ channels reverses the inhibitory action of atriopeptin on secretagogue-stimulated ACTH release by perifused isolated rat anterior pituitary cells.
Positive_regulation (secretagogue-stimulated) of Localization (release) of atriopeptin in anterior pituitary
18) Confidence 0.27 Published 1990 Journal J. Endocrinol. Section Title Doc Link 2169519 Disease Relevance 0 Pain Relevance 0.07
Basal and stretch-augmented natriuretic peptide secretion by quiescent rat atria.
Positive_regulation (augmented) of Localization (secretion) of natriuretic peptide associated with natriuresis
19) Confidence 0.02 Published 1990 Journal Am. J. Physiol. Section Title Doc Link 2146883 Disease Relevance 0.34 Pain Relevance 0.08
Alternately, increased release of the vasodilatory peptide atrial natriuretic factor has been described with rapid volume expansion [23,24].
Positive_regulation (increased) of Localization (release) of atrial natriuretic factor associated with natriuresis
20) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC468893 Disease Relevance 0.44 Pain Relevance 0.04

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