INT15157

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 15.49
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INPP5K) endoplasmic reticulum (INPP5K) plasma membrane (INPP5K)
nucleus (INPP5K) cytoplasm (INPP5K)
Anatomy Link Frequency
M cells 2
domes 2
tube 1
ileum 1
crops 1
INPP5K (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 480 100.00 Very High Very High Very High
Inflammation 157 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
palliative 7 98.48 Very High Very High Very High
Piles 48 97.52 Very High Very High Very High
Potency 9 96.44 Very High Very High Very High
Opioid 1 88.16 High High
dexamethasone 12 87.76 High High
Neuropeptide 6 87.52 High High
corticosteroid 1 86.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 147 100.00 Very High Very High Very High
Syndrome 41 100.00 Very High Very High Very High
Inflammatory Bowel Disease 576 99.76 Very High Very High Very High
Disease 223 99.20 Very High Very High Very High
Ileitis 96 97.84 Very High Very High Very High
Anorectal Disorders 48 97.52 Very High Very High Very High
Chronic Disease 25 95.28 Very High Very High Very High
Apoptosis 132 95.04 Very High Very High Very High
Granuloma 24 95.04 Very High Very High Very High
Frailty 123 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endoscopic findings of these 6 UC patients were mild, with few erosions and redness within the PPs (Fig. 3A).
Gene_expression (redness) of PPs associated with inflammatory bowel disease
1) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.22 Pain Relevance 0.04
According to the classification that we previously proposed, the macroscopic appearance of PPs was divided into two categories: type E, consisting of a nodular or convoluted elevation pattern; and type F, consisting of a flat pattern [6].
Gene_expression (appearance) of PPs
2) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.91 Pain Relevance 0.16
It is unknown whether variations in the macroscopic appearance of PPs have any relationship to patients’ susceptibility to disease or to the presence of disease.
Gene_expression (appearance) of PPs associated with disease
3) Confidence 0.60 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.49 Pain Relevance 0.14
Those patients with higher PPS scores may have longer length of stays, although all patients may not be comparable.
Gene_expression (scores) of PPS
4) Confidence 0.58 Published 2003 Journal Health Qual Life Outcomes Section Body Doc Link PMC155633 Disease Relevance 0.24 Pain Relevance 0.27
The FAE on the PPs’ domes and the surrounding villi was examined by magnifying endoscopy.
Gene_expression (domes) of PPs in domes
5) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.92 Pain Relevance 0.11
Electron microscopic observation using the biopsy specimens taken from the PPs showed the presence of M cells in the FAE (Fig. 5A) on the PPs’ domes in every case that was examined.
Gene_expression (presence) of PPs in M cells
6) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.85 Pain Relevance 0.03
Ileal lesions were present within the PPs in 6 UC patients, 4 of whom had pancolitis and 2 of whom had proctitis; of the 6 UC patients, disease activity was mild in 3 and moderate in 3.
Gene_expression (present) of PPs associated with inflammatory bowel disease, piles and disease
7) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.25 Pain Relevance 0.08
The FAE located over the PPs’ domes that were surrounded by scattered, atrophic villi is likely to be more exposed to luminal antigens and infectious agents, for which M cells function as a portal of entry [3, 4].
Gene_expression (domes) of PPs in M cells
8) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.76 Pain Relevance 0
There was no difference in the age distribution of the type E and type F PPs between the 140 controls and the 18 UC patients; in both groups, type E PPs were exclusively observed in individuals younger than 30 years, while type F PPs were predominantly observed in individuals older than 30 years.
Gene_expression (observed) of PPs associated with inflammatory bowel disease
9) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.22 Pain Relevance 0.08
There was no difference in the age distribution of the type E and type F PPs between the 140 controls and the 18 UC patients; in both groups, type E PPs were exclusively observed in individuals younger than 30 years, while type F PPs were predominantly observed in individuals older than 30 years.
Gene_expression (observed) of PPs associated with inflammatory bowel disease
10) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.14 Pain Relevance 0.08
In the 3 patients treated with mesalazine alone, there was no change in the magnified endoscopic appearance of PPs with treatment (Fig. 4A and B).
Gene_expression (appearance) of PPs
11) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.12 Pain Relevance 0.06
In addition, most CD patients examined had irregularly even PPs domes surrounded by sparse villi.
Gene_expression (domes) of PPs in domes associated with disease
12) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.17 Pain Relevance 0.13
Gonzales et al were the first researchers to show that IVIG reduced CSF inflammatory cytokine levels in PPS patients,41 and this observation provided the rationale for trying IVIG as a therapy in PPS.
Gene_expression (reduced) of PPS associated with inflammation, syndrome and cytokine
13) Confidence 0.52 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.28 Pain Relevance 0.42
This is the first study to document the detailed macroscopic appearance of PPs in the terminal ileum of UC patients using magnified endoscopy.
Gene_expression (appearance) of PPs in ileum associated with inflammatory bowel disease
14) Confidence 0.52 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.74 Pain Relevance 0
90% confluence prior to the addition of osteoinductive media containing PPS at concentrations of 0.0, 1.0, 2.0, 5.0 and 10 ?
Gene_expression (containing) of PPS
15) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.08 Pain Relevance 0.04
M hydrocortisone in the presence of concentrations of PPS of 0.0, 1.0, 2.0, 5.0 and 10 ?
Gene_expression (concentrations) of PPS
16) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0.03
l DMEM-high glucose (+10% FBS) containing PPS and 3H-thymidine (Perkin-Elmer Life and Analytical Science, Knoxfield, Victoria, Australia) to afford final well concentrations of 0, 0.1, 0.5, 1.0, 2.5, 5.0, 10.0 and 20.0 ?
Gene_expression (containing) of PPS
17) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
Significantly, immunostaining of serial sections for collagen type I clearly demonstrated diminished levels of this protein in pellets grown in the presence of PPS.
Gene_expression (presence) of PPS
18) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.07 Pain Relevance 0
In the 5-day cultures, lower but significant (P < 0.001 to 0.05) stimulation of collagen type II synthesis by MPCs was still evident at PPS concentrations up to 20 ?
Gene_expression (concentrations) of PPS
19) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
Effects of PPS, hyaluronan, dextran sulfate and heparin on proteoglycan biosynthesis by MPCs
Gene_expression (Effects) of PPS
20) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.13 Pain Relevance 0

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