INT151574

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.63
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aifm1) mitochondrion (Aifm1) oxidoreductase activity (Aifm1)
nucleus (Aifm1) DNA binding (Aifm1) cytoplasm (Aifm1)
Anatomy Link Frequency
AsPC-1 1
BxPC-3 1
Aifm1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 36 99.28 Very High Very High Very High
alcohol 14 50.00 Quite Low
Paracetamol 2 50.00 Quite Low
ischemia 3 37.80 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 56 98.46 Very High Very High Very High
Cancer 7 97.24 Very High Very High Very High
Death 22 95.72 Very High Very High Very High
Pancreatic Cancer 21 92.00 High High
Stress 7 91.80 High High
Coronary Heart Disease 9 81.28 Quite High
Acute Liver Failure 2 67.24 Quite High
Reperfusion Injury 2 38.56 Quite Low
Hypertrophic Cardiomyopathy 1 37.28 Quite Low
Cleidocranial Dysplasia 1 36.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitochondrial GSH and adenosine triphosphate (ATP) levels, cytochrome C and apoptosis-inducing factor (AIF) leakage, mitochondrial swelling and membrane potential were determined.
Gene_expression (leakage) of AIF
1) Confidence 0.62 Published 2008 Journal Liver Int. Section Body Doc Link 18435715 Disease Relevance 0.07 Pain Relevance 0
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Gene_expression (expression) of AIF associated with qutenza, cancer and apoptosis
2) Confidence 0.55 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.77 Pain Relevance 0.86
Our finding of unaltered cytosolic AIF expression does not seem to favor the involvement of a caspase-independent apoptotic process in ethanol-induced cell death.
Gene_expression (expression) of AIF associated with apoptosis and death
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.86 Pain Relevance 0
Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.
Gene_expression (expression) of AIF in BxPC-3 associated with qutenza
4) Confidence 0.19 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.97 Pain Relevance 0.74
Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.
Gene_expression (expression) of AIF in AsPC-1 associated with qutenza
5) Confidence 0.06 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.97 Pain Relevance 0.74

General Comments

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