INT151580

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.45
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 77.44 Quite High
cytokine 20 74.48 Quite High
Inflammation 10 74.08 Quite High
tolerance 18 71.04 Quite High
alcohol 12 50.00 Quite Low
qutenza 4 25.00 Low Low
agonist 10 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 540 99.32 Very High Very High Very High
Aging 372 94.28 High High
Diabetes Mellitus 48 89.28 High High
Targeted Disruption 8 83.36 Quite High
Neurodegenerative Disease 1 80.80 Quite High
Cv Unclassified Under Development 4 77.44 Quite High
Insulin Resistance 59 74.48 Quite High
INFLAMMATION 10 74.08 Quite High
Impaired Glucose Tolerance 19 71.04 Quite High
Hepatocellular Cancer 2 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, increased phosphorylation of AMPK and ACC by isodihydrocapsiate was significantly reduced by radicicol, an LKB1 destabilizer, suggesting that increased glucose uptake in L6 cells with isodihydrocapsiate treatment is predominantly accomplished by a LKB1-mediated AMPK activation pathway.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
1) Confidence 0.33 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.17 Pain Relevance 0
Our findings suggest that the phosphorylation of AMPK at Thr172 may be influenced by the expression of PP2A but less likely PP2C?
Negative_regulation (influenced) of Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.29 Pain Relevance 0.04
Furthermore, direct inhibition of AMPK activity with either compound C or siRNA in the presence of IL-6 blocked phosphorylation of AS160 and impeded glucose uptake.
Negative_regulation (inhibition) of Phosphorylation (presence) of AMPK
3) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.23 Pain Relevance 0.06
Short-term leptin treatment at
                   physiological level (1.0 nM) reduced AMPK phosphorylation in young
                       ob/ob mice but not other groups. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK associated with obesity
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.71 Pain Relevance 0
While obesity and age alone failed to affect AMPK and its
                   phosphorylation, the combination of the two significantly attenuated AMPK
                   phosphorylation but not total AMPK expression. 
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of AMPK associated with obesity
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.80 Pain Relevance 0
Interestingly, combining
               obesity and age significantly attenuated phosphorylation of ERK and AMPK, the
               effects of which were ablated and unaffected, respectively, by leptin treatment.
               
Neg (unaffected) Negative_regulation (ablated) of Phosphorylation (phosphorylation) of AMPK associated with obesity
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.98 Pain Relevance 0.07
Inhibition of AMPK reduced p38 MAPK phosphorylation, suggesting that AMPK lies upstream of p38 MAPK.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
7) Confidence 0.02 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.27 Pain Relevance 0

General Comments

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