INT151581

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.97
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
skeletal muscles 2
myotube 2
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 87.84 High High
tolerance 24 69.28 Quite High
alcohol 24 50.00 Quite Low
qutenza 8 25.00 Low Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 195 97.54 Very High Very High Very High
Diabetes Mellitus 59 97.32 Very High Very High Very High
Aging 124 94.28 High High
Cv Unclassified Under Development 6 87.84 High High
Neurodegenerative Disease 2 86.92 High High
Insulin Resistance 18 74.00 Quite High
Impaired Glucose Tolerance 32 69.92 Quite High
Injury 2 58.64 Quite High
Stress 25 50.00 Quite Low
Coronary Heart Disease 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In L6 myotube cells, phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) and glucose uptake were significantly increased, whereas these effects were attenuated by an AMPK inhibitor, compound C.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK in myotube
1) Confidence 0.61 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.16 Pain Relevance 0
In addition, increased phosphorylation of AMPK and ACC by isodihydrocapsiate was significantly reduced by radicicol, an LKB1 destabilizer, suggesting that increased glucose uptake in L6 cells with isodihydrocapsiate treatment is predominantly accomplished by a LKB1-mediated AMPK activation pathway.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.54 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.17 Pain Relevance 0
This is consistent with our current finding of elevated phosphorylation of AMPK?
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of AMPK
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.39 Pain Relevance 0.08
However, phosphorylation of both AMPK and ACC was increased by acute ethanol exposure (both absolute value and phosphorylated-to-pan protein ratio), the effect of which was accentuated by ADH.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.06 Pain Relevance 0.03
While obesity and age alone failed to affect AMPK and its
                   phosphorylation, the combination of the two significantly attenuated AMPK
                   phosphorylation but not total AMPK expression. 
Neg (not) Positive_regulation (attenuated) of Phosphorylation (phosphorylation) of AMPK associated with obesity
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.75 Pain Relevance 0
However, Lee et al. revealed that berberine increased AMPK phosphorylation, but it did not activate p38 [10].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK
6) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.13 Pain Relevance 0
Cheng et al. found that berberine strongly promotes the phosphorylation of AMPK and p38 MAPK on L6 rat skeletal muscles [21].
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of AMPK in skeletal muscles
7) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.31 Pain Relevance 0

General Comments

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