INT151583

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.68
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 27 99.38 Very High Very High Very High
alcohol 36 99.20 Very High Very High Very High
antagonist 32 99.16 Very High Very High Very High
tolerance 19 91.28 High High
fibrosis 65 82.72 Quite High
Cannabinoid 66 80.24 Quite High
Endocannabinoid 70 77.60 Quite High
qutenza 4 25.00 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
ketamine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 351 100.00 Very High Very High Very High
Diabetes Mellitus 29 99.84 Very High Very High Very High
Aging 248 99.32 Very High Very High Very High
Targeted Disruption 29 97.92 Very High Very High Very High
Metabolic Disorder 8 95.92 Very High Very High Very High
Impaired Glucose Tolerance 31 91.92 High High
Cystic Fibrosis 64 82.72 Quite High
Appetite Loss 16 82.52 Quite High
Alcoholic Cardiomyopathy 12 82.20 Quite High
Coronary Heart Disease 19 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results support the development of isodihydrocapsiate as a potential therapeutic agent to target AMPK in type 2 diabetes.
Regulation (target) of AMPK associated with diabetes mellitus
1) Confidence 0.21 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.26 Pain Relevance 0
Recently, it has been recognized that PPAR agonists have physiological effects by modulating the activity of AMP-activated protein kinase (AMPK), an important cellular energy sensor [5–9].
Regulation (modulating) of AMPK associated with agonist
2) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.16 Pain Relevance 0.13
Effect of acute ethanol challenge on AMPK, ACC and LKB1 in FVB and ADH mice
Regulation (Effect) of AMPK
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.04
To monitor the change in the AMPK degrading phosphatase, expression of protein phosphatase 2A (PP2A) and protein phosphatase 2C?
Regulation (change) of AMPK degrading phosphatase
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.58 Pain Relevance 0.07
This study was designed to examine the impact of cardiac-specific overexpression of alcohol dehydrogenase (ADH) on ethanol-induced change in cardiac contractile function, intracellular Ca2+ homeostasis, insulin and AMP-dependent kinase (AMPK) signaling.


Regulation (change) of AMPK associated with alcohol
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.34 Pain Relevance 0.18
Furthermore, while ghrelin stimulates hypothalamic AMPK activity in wild-type mice, it has no effect on AMPK in CB1-KO or in CB1 antagonist-treated mice.
Neg (no) Regulation (effect) of AMPK associated with antagonist
6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.23 Pain Relevance 0.33
In CB1-KO animals, THC did not modulate hypothalamic AMPK activity (85±16% of control, Fig. 1B), suggesting that the AMPK-stimulating effect of THC is via CB1.
Neg (not) Regulation (d not mo) of AMPK
7) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.04
Influence of age and ob/ob obesity on Akt, eNOS and
                   AMPK
Regulation (Influence) of AMPK associated with obesity
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.93 Pain Relevance 0
A number of signaling molecules have been shown to participate in obesity and
                   aging-induced biological responses and regulation of cardiac function, including
                   Akt, the Akt downstream signal eNOS and the cellular fuel AMPK [29], [30]. 
Regulation (regulation) of AMPK associated with aging and obesity
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.96 Pain Relevance 0
Levels of p-AMPK were not significantly altered in the CFTR depletion condition whereas the mass of total AMPK was significantly reduced resulting in an upward, albeit moderate, shift of the p-AMPK to total AMPK ratio, an index of AMPK activity.
Neg (not) Regulation (altered) of AMPK
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.06 Pain Relevance 0.03
These results were unexpected giving that numerous studies have reported that p-ACC remained under the control of AMPK.
Regulation (control) of AMPK
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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