INT151584

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.72
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
muscle 1
myotube 1
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 70 97.36 Very High Very High Very High
Cannabinoid 66 92.00 High High
antagonist 32 91.28 High High
cytokine 52 81.52 Quite High
tolerance 37 71.04 Quite High
Cannabinoid receptor 2 66.00 Quite High
alcohol 24 50.00 Quite Low
ischemia 10 45.12 Quite Low
qutenza 4 25.00 Low Low
agonist 57 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 31 98.24 Very High Very High Very High
Diabetes Mellitus 55 91.32 High High
Hyperlipidemia 4 84.36 Quite High
Insulin Resistance 142 80.24 Quite High
Stress 18 75.28 Quite High
Hepatocellular Cancer 3 71.92 Quite High
Impaired Glucose Tolerance 36 71.04 Quite High
Obesity 82 60.80 Quite High
Pathologic Processes 2 57.52 Quite High
Cardiovascular Disease 2 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In L6 myotube cells, phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) and glucose uptake were significantly increased, whereas these effects were attenuated by an AMPK inhibitor, compound C.
Negative_regulation (inhibitor) of AMPK in myotube
1) Confidence 0.38 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.16 Pain Relevance 0
Similarly, AMPK activation attenuates TG synthesis via the inhibition of LXR?
Negative_regulation (attenuates) of AMPK
2) Confidence 0.28 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.51 Pain Relevance 0
, two protein phosphotases, are known to dephosphorylate and inactivate AMPK [23].
Negative_regulation (inactivate) of AMPK
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0
Effect of AMPK inhibition on acute ethanol exposure-induced changes in cell shortening
Negative_regulation (inhibition) of AMPK
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Activation of AMPK by IL-6 was previously observed in skeletal muscle, whereas diminished AMPK activity was found in muscle from the IL-6 knockout mice (24).
Negative_regulation (diminished) of AMPK in muscle associated with targeted disruption
5) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.23 Pain Relevance 0.07
Furthermore, direct inhibition of AMPK activity with either compound C or siRNA in the presence of IL-6 blocked phosphorylation of AS160 and impeded glucose uptake.
Negative_regulation (inhibition) of AMPK
6) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.22 Pain Relevance 0.06
Correspondingly, both the genetic lack of CB1 and the pharmacological blockade of CB1 inhibited the effect of ghrelin on AMPK activity.
Negative_regulation (inhibited) of AMPK
7) Confidence 0.08 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2258435 Disease Relevance 0.17 Pain Relevance 0.45
0.0038; Fig. 1B), while rimonabant significantly decreased basal AMPK activity (75.7±8.4% of control, P?
Negative_regulation (decreased) of AMPK
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.03
was knocked down with siRNA, a robust 80% reduction of AMPK protein was detected, and, therefore, phosphorylation of AMPK, ACC, and AS160 by IL-6 was completely impaired.


Negative_regulation (reduction) of AMPK
9) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.08 Pain Relevance 0.07
Inhibition of AMPK reduced p38 MAPK phosphorylation, suggesting that AMPK lies upstream of p38 MAPK.
Negative_regulation (Inhibition) of AMPK
10) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.27 Pain Relevance 0

General Comments

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