INT151586

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 51
Total Number 53
Disease Relevance 18.70
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
muscle 4
skeletal muscle 4
myocardium 3
plasma 1
endothelial cells 1
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 4 100.00 Very High Very High Very High
Cannabinoid 165 99.98 Very High Very High Very High
cytokine 120 99.84 Very High Very High Very High
agonist 533 99.64 Very High Very High Very High
Endocannabinoid 175 99.50 Very High Very High Very High
ischemia 57 99.18 Very High Very High Very High
alcohol 120 98.54 Very High Very High Very High
Cannabinoid receptor 5 95.28 Very High Very High Very High
Kinase C 23 94.64 High High
antagonist 96 92.56 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 283 99.92 Very High Very High Very High
Hyperlipidemia 44 99.92 Very High Very High Very High
Insulin Resistance 513 99.90 Very High Very High Very High
Hepatocellular Cancer 12 99.84 Very High Very High Very High
Impaired Glucose Tolerance 156 99.48 Very High Very High Very High
Hypertrophy 67 99.20 Very High Very High Very High
Cv Unclassified Under Development 55 99.18 Very High Very High Very High
Stress 188 99.14 Very High Very High Very High
Hypoxia 36 99.12 Very High Very High Very High
Coronary Heart Disease 81 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that a synthetic structural isomer of dihydrocapsiate, isodihydrocapsiate (8-methylnonanoic acid 3-hydroxy-4-methoxy benzyl ester) improves type 2 diabetes by activating AMPK through the LKB1 pathway.
Positive_regulation (activating) of AMPK associated with diabetes mellitus
1) Confidence 0.54 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.15 Pain Relevance 0
Therefore, the agents that activate AMPK are beneficial in the treatment of insulin resistance and diabetes [44].
Positive_regulation (activate) of AMPK associated with diabetes mellitus and insulin resistance
2) Confidence 0.46 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.48 Pain Relevance 0.03
Nonetheless, recent finding from Crabb and colleagues suggested that ethanol is capable of inhibiting (rather than activating) hydrogen peroxide-induced AMPK activation in hepatoma cells [23], suggesting a likely paradoxical role of AMPK in ethanol-elicited effects.
Positive_regulation (activation) of AMPK associated with hepatocellular cancer
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.32 Pain Relevance 0.03
Result from our current study revealed that acute ethanol treatment turned on LKB1 phosphorylation with a further increase in ADH mice, supporting a likely role of LKB1 in the ADH and ethanol-induced AMPK activation (shown by phosphorylation of AMPK and ACC).
Positive_regulation (activation) of AMPK
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.11 Pain Relevance 0.03
We went on to examine the involvement of LKB1 in ADH and ethanol-induced response in AMPK/ACC activation.
Positive_regulation (activation) of AMPK
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
AMPK activation induces fatty acid oxidation in liver and heart, inhibits hepatic lipogenesis and adipocyte differentiation, and stimulates glucose uptake in muscle [30, 31].
Positive_regulation (activation) of AMPK in muscle
6) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.32 Pain Relevance 0.06
AMPK activation is initiated with phosphorylation of threonine-172 in the catalytic domain of ?
Positive_regulation (activation) of AMPK
7) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.23 Pain Relevance 0.03
Thus, AMPK activation negatively regulates the mTOR/S6K1 pathway.
Positive_regulation (activation) of AMPK
8) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.34 Pain Relevance 0.04
Moreover, AMPK activation by PPAR agonists seems to be independent of the receptor activation.
Positive_regulation (activation) of AMPK associated with agonist
9) Confidence 0.31 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2929615 Disease Relevance 0.08 Pain Relevance 0.31
AMPK activation by metformin or dithiolethiones represses LXR?
Positive_regulation (activation) of AMPK
10) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.15 Pain Relevance 0
Similarly, AMPK activation attenuates TG synthesis via the inhibition of LXR?
Positive_regulation (activation) of AMPK
11) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.50 Pain Relevance 0
agonists including fenofibrate and WY14643 stimulate eNOS activity and NO production in human umbilical vein endothelial cells in association with AMPK activation [69, 70].
Positive_regulation (activation) of AMPK in endothelial cells associated with agonist
12) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.59 Pain Relevance 0.15
AMPK activation regulates physiological and pathological responses in diverse tissues.
Positive_regulation (activation) of AMPK
13) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.34 Pain Relevance 0.06
Rosiglitazone promotes AMPK-mediated insulin secretion via the phosphorylation of Kir6.2 subunit of the potassium (ATP) channel in ?
Positive_regulation (promotes) of AMPK
14) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 1.14 Pain Relevance 0
Therefore, ADH and ethanol-induced effect on protein phosphatases (especially PP2A) may play a role in hyperactivated AMPK signaling in our current experimental setting.
Positive_regulation (hyperactivated) of AMPK
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.27 Pain Relevance 0.03
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Positive_regulation (hyperactivated) of AMPK
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.40 Pain Relevance 0.08
Consistently, troglitazone caused two-fold increases in 2-deoxy-d-glucose uptake in skeletal muscle through AMPK activation.
Positive_regulation (activation) of AMPK in skeletal muscle
17) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.39 Pain Relevance 0.04
Elevated level of AMP induces allosteric stimulation of AMPK.
Positive_regulation (stimulation) of AMPK
18) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.13 Pain Relevance 0.03
Several TZDs have been shown to recover insulin resistance via AMPK activation [59–62].
Positive_regulation (activation) of AMPK associated with insulin resistance
19) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 1.16 Pain Relevance 0
Recently, BLX-1002, a novel TZD with no PPAR affinity, activates AMPK in ?
Positive_regulation (activates) of AMPK
20) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.74 Pain Relevance 0

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