INT151587

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) kinase activity (Stk11)
Anatomy Link Frequency
muscle 1
Stk11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 99.36 Very High Very High Very High
tolerance 12 50.44 Quite High
qutenza 4 25.00 Low Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 15 99.92 Very High Very High Very High
Targeted Disruption 6 91.04 High High
Insulin Resistance 80 53.88 Quite High
Impaired Glucose Tolerance 6 50.44 Quite High
Obesity 40 24.80 Low Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Hyperinsulinism 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that a synthetic structural isomer of dihydrocapsiate, isodihydrocapsiate (8-methylnonanoic acid 3-hydroxy-4-methoxy benzyl ester) improves type 2 diabetes by activating AMPK through the LKB1 pathway.
Positive_regulation (activating) of LKB1 associated with diabetes mellitus
1) Confidence 0.38 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.16 Pain Relevance 0
However, recent observations indicate that activation of AMPK by cytokines, such as adiponectin, involves activation of LKB1 in C2C12 cells (39).
Positive_regulation (activation) of LKB1 associated with cytokine
2) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.09 Pain Relevance 0.05
Moreover, deficiency of LKB1 in skeletal muscle was reported to prevent AMPK activation and glucose uptake during contraction (37), although muscle contraction activates AMPK by a mechanism independent of direct activation of LKB1 (38).
Positive_regulation (activation) of LKB1 in muscle
3) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.20 Pain Relevance 0.07

General Comments

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